Reflections on the European union Eurythron network meeting "molecular control of erythropoiesis," September 22-23, 2005, Istituto Superiore di Sanità, Rome, Italy

Anna Rita Migliaccio, Sjaak Philipsen

Research output: Contribution to journalArticlepeer-review

Abstract

Red blood cells (RBCs) mediate oxygen transport throughout the body, a function that is essential for life. RBCs are continuously produced via a process called erythropoiesis. Anemias (insufficient numbers of functional RBCs), caused by failure of erythropoiesis, are a major cause of disease worldwide. Hereditary anemias constitute the most common human genetic disorders; they have no effective cure yet. The European research training network Eurythron follows a multidisciplinary approach to clarify the important molecular mechanisms in normal and pathological erythropoiesis, with a view to develop novel therapies to cure the anemias. The aim is to generate a comprehensive molecular description of mechanisms governing specification of hematopoietic stem cells in embryogenesis, lineage commitment, differentiation, and postmitotic maturation of RBCs. We report on the Eurythron meeting in Rome, in which novel approaches in stem cell and erythroid cell biology, including in vitro expansion of primary cells, biochemistry of receptor/signal transduction complexes and transcription factors, and (epi)genetics, were discussed.

Original languageEnglish
Pages (from-to)2478-2482
Number of pages5
JournalStem Cells
Volume24
Issue number11
DOIs
StatePublished - 2006
Externally publishedYes

Keywords

  • Commitment
  • Erythropoiesis
  • Hematopoiesis
  • Hematopoietic stem cells
  • Networks

Fingerprint

Dive into the research topics of 'Reflections on the European union Eurythron network meeting "molecular control of erythropoiesis," September 22-23, 2005, Istituto Superiore di Sanità, Rome, Italy'. Together they form a unique fingerprint.

Cite this