Reduction of Pten dose leads to neoplastic development in multiple organs of PtenshRNA mice

Hong Shen-Li; Susan Koujak; Matthias Szablocs; Ramon Parsons

doi:10.4161/cbt.10.11.13814

Reduction of Pten dose leads to neoplastic development in multiple organs of Pten^shRNA mice

Hong Shen-Li, Susan Koujak, Matthias Szablocs, Ramon Parsons

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

To address the impact of partial reduction of Pten on tumor initiation, we generated Pten^shRNA mice, in which PTEN expression was reduced below normal levels in various tissues. Pten^shRNA mice frequently developed lymphoid and prostatic hyperplasia, splenomegaly and sebaceous adenomas. Our observations support the notion that partial reduction of the dose of Pten with shRNA is sufficient to induce neoplastic disease in multiple organ systems.

Original language	English
Pages (from-to)	1194-1200
Number of pages	7
Journal	Cancer Biology and Therapy
Volume	10
Issue number	11
DOIs	https://doi.org/10.4161/cbt.10.11.13814
State	Published - 1 Dec 2010
Externally published	Yes

Keywords

Haploinsufficiency
Neoplasia
Pten
RNAi
Tumor suppressor
shRNA

Access to Document

10.4161/cbt.10.11.13814

Cite this

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title = "Reduction of Pten dose leads to neoplastic development in multiple organs of PtenshRNA mice",

abstract = "To address the impact of partial reduction of Pten on tumor initiation, we generated PtenshRNA mice, in which PTEN expression was reduced below normal levels in various tissues. PtenshRNA mice frequently developed lymphoid and prostatic hyperplasia, splenomegaly and sebaceous adenomas. Our observations support the notion that partial reduction of the dose of Pten with shRNA is sufficient to induce neoplastic disease in multiple organ systems.",

keywords = "Haploinsufficiency, Neoplasia, Pten, RNAi, Tumor suppressor, shRNA",

author = "Hong Shen-Li and Susan Koujak and Matthias Szablocs and Ramon Parsons",

note = "Funding Information: We thank Dr. Greg Hannon for providing advice and assistance for cloning shRNA vectors targeting Pten. This work is supported by NCI grant CA082783.",

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doi = "10.4161/cbt.10.11.13814",

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T1 - Reduction of Pten dose leads to neoplastic development in multiple organs of PtenshRNA mice

AU - Shen-Li, Hong

AU - Koujak, Susan

AU - Szablocs, Matthias

AU - Parsons, Ramon

N1 - Funding Information: We thank Dr. Greg Hannon for providing advice and assistance for cloning shRNA vectors targeting Pten. This work is supported by NCI grant CA082783.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - To address the impact of partial reduction of Pten on tumor initiation, we generated PtenshRNA mice, in which PTEN expression was reduced below normal levels in various tissues. PtenshRNA mice frequently developed lymphoid and prostatic hyperplasia, splenomegaly and sebaceous adenomas. Our observations support the notion that partial reduction of the dose of Pten with shRNA is sufficient to induce neoplastic disease in multiple organ systems.

AB - To address the impact of partial reduction of Pten on tumor initiation, we generated PtenshRNA mice, in which PTEN expression was reduced below normal levels in various tissues. PtenshRNA mice frequently developed lymphoid and prostatic hyperplasia, splenomegaly and sebaceous adenomas. Our observations support the notion that partial reduction of the dose of Pten with shRNA is sufficient to induce neoplastic disease in multiple organ systems.

KW - Haploinsufficiency

KW - Neoplasia

KW - Pten

KW - RNAi

KW - Tumor suppressor

KW - shRNA

UR - https://www.scopus.com/pages/publications/78649861614

U2 - 10.4161/cbt.10.11.13814

DO - 10.4161/cbt.10.11.13814

M3 - Article

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AN - SCOPUS:78649861614

SN - 1538-4047

VL - 10

SP - 1194

EP - 1200

JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

IS - 11