Reduction of parathyroid hormone with vitamin D supplementation in blacks: A randomized controlled trial

Paulette D. Chandler; Foluso Agboola; Kimmie Ng; Jamil B. Scott; Bettina F. Drake; Gary G. Bennett; Andrew T. Chan; Bruce W. Hollis; Karen M. Emmons; Charles S. Fuchs; Edward L. Giovannucci

doi:10.1186/s40795-015-0024-8

Reduction of parathyroid hormone with vitamin D supplementation in blacks: A randomized controlled trial

Paulette D. Chandler, Foluso Agboola, Kimmie Ng, Jamil B. Scott, Bettina F. Drake, Gary G. Bennett, Andrew T. Chan, Bruce W. Hollis, Karen M. Emmons, Charles S. Fuchs, Edward L. Giovannucci

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. Methods: During 3 winters from 2007 to 2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. Results: The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d (-2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p < 0.001). Conclusion: We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Trial registration: Clinical Trials.gov:

Original language	English
Article number	26
Journal	BMC Nutrition
Volume	1
Issue number	1
DOIs	https://doi.org/10.1186/s40795-015-0024-8
State	Published - 30 Jul 2015
Externally published	Yes

Keywords

Blacks
Parathyroid hormone
Supplementation
Vitamin D

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10.1186/s40795-015-0024-8

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@article{b44fa2481a484d049fa8129439baa730,

title = "Reduction of parathyroid hormone with vitamin D supplementation in blacks: A randomized controlled trial",

abstract = "Background: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. Methods: During 3 winters from 2007 to 2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. Results: The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d (-2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p < 0.001). Conclusion: We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Trial registration: Clinical Trials.gov:",

keywords = "Blacks, Parathyroid hormone, Supplementation, Vitamin D",

author = "Chandler, {Paulette D.} and Foluso Agboola and Kimmie Ng and Scott, {Jamil B.} and Drake, {Bettina F.} and Bennett, {Gary G.} and Chan, {Andrew T.} and Hollis, {Bruce W.} and Emmons, {Karen M.} and Fuchs, {Charles S.} and Giovannucci, {Edward L.}",

note = "Publisher Copyright: {\textcopyright} 2015 Chandler et al.",

year = "2015",

month = jul,

day = "30",

doi = "10.1186/s40795-015-0024-8",

language = "English",

volume = "1",

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T1 - Reduction of parathyroid hormone with vitamin D supplementation in blacks

T2 - A randomized controlled trial

AU - Chandler, Paulette D.

AU - Agboola, Foluso

AU - Ng, Kimmie

AU - Scott, Jamil B.

AU - Drake, Bettina F.

AU - Bennett, Gary G.

AU - Chan, Andrew T.

AU - Hollis, Bruce W.

AU - Emmons, Karen M.

AU - Fuchs, Charles S.

AU - Giovannucci, Edward L.

PY - 2015/7/30

Y1 - 2015/7/30

N2 - Background: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. Methods: During 3 winters from 2007 to 2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. Results: The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d (-2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p < 0.001). Conclusion: We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Trial registration: Clinical Trials.gov:

AB - Background: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. Methods: During 3 winters from 2007 to 2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. Results: The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d (-2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p < 0.001). Conclusion: We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Trial registration: Clinical Trials.gov:

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KW - Supplementation

KW - Vitamin D

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Reduction of parathyroid hormone with vitamin D supplementation in blacks: A randomized controlled trial

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