Reduction in 2-deoxy-d-glucose analgesia following acute, but not chronic antidepressant treatment

Richard J. Bodnar; Maria Teresa Romero; Benjamin Kest; Eric A. Stone

doi:10.1007/BF00217063

Reduction in 2-deoxy-d-glucose analgesia following acute, but not chronic antidepressant treatment

Richard J. Bodnar, Maria Teresa Romero, Benjamin Kest, Eric A. Stone

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Acute, but not chronic, antidepressant treatment potentiates the analgesic responses following cold-water swims. The present study evaluated the effects of acute (10 mg/kg) and chronic (10 mg/kg, twice daily over 7 days) pretreatment with desipramine (DMI) upon the analgesic response following 2-deoxy-d-glucose (2 dG) in rats as measured by the jump test. Acute, but not chronic, DMI pretreatment significantly reduced 2 dG analgesia. These effects are discussed in terms of the heterogeneity of pain-inhibitory responses.

Original language	English
Pages (from-to)	207-208
Number of pages	2
Journal	Psychopharmacology
Volume	91
Issue number	2
DOIs	https://doi.org/10.1007/BF00217063
State	Published - Feb 1987
Externally published	Yes

Keywords

2-Deoxy-d-glucose
Analgesia
Desipramine

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10.1007/BF00217063

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title = "Reduction in 2-deoxy-d-glucose analgesia following acute, but not chronic antidepressant treatment",

abstract = "Acute, but not chronic, antidepressant treatment potentiates the analgesic responses following cold-water swims. The present study evaluated the effects of acute (10 mg/kg) and chronic (10 mg/kg, twice daily over 7 days) pretreatment with desipramine (DMI) upon the analgesic response following 2-deoxy-d-glucose (2 dG) in rats as measured by the jump test. Acute, but not chronic, DMI pretreatment significantly reduced 2 dG analgesia. These effects are discussed in terms of the heterogeneity of pain-inhibitory responses.",

keywords = "2-Deoxy-d-glucose, Analgesia, Desipramine",

author = "Bodnar, {Richard J.} and Romero, {Maria Teresa} and Benjamin Kest and Stone, {Eric A.}",

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AU - Stone, Eric A.

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Y1 - 1987/2

N2 - Acute, but not chronic, antidepressant treatment potentiates the analgesic responses following cold-water swims. The present study evaluated the effects of acute (10 mg/kg) and chronic (10 mg/kg, twice daily over 7 days) pretreatment with desipramine (DMI) upon the analgesic response following 2-deoxy-d-glucose (2 dG) in rats as measured by the jump test. Acute, but not chronic, DMI pretreatment significantly reduced 2 dG analgesia. These effects are discussed in terms of the heterogeneity of pain-inhibitory responses.

AB - Acute, but not chronic, antidepressant treatment potentiates the analgesic responses following cold-water swims. The present study evaluated the effects of acute (10 mg/kg) and chronic (10 mg/kg, twice daily over 7 days) pretreatment with desipramine (DMI) upon the analgesic response following 2-deoxy-d-glucose (2 dG) in rats as measured by the jump test. Acute, but not chronic, DMI pretreatment significantly reduced 2 dG analgesia. These effects are discussed in terms of the heterogeneity of pain-inhibitory responses.

KW - 2-Deoxy-d-glucose

KW - Analgesia

KW - Desipramine

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Reduction in 2-deoxy-d-glucose analgesia following acute, but not chronic antidepressant treatment

Abstract

Keywords

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