Reducing perioperative blood loss with antifibrinolytics and antifibrinolytic-like agents for patients undergoing total hip and total knee arthroplasty

Bhaveen H. Kapadia; Barrett B. Torre; Nicholas Ullman; Andrew Yang; Matthew A. Harb; Preston W. Grieco; Jared M. Newman; Steven F. Harwin; Aditya V. Maheshwari

doi:10.1016/j.jor.2019.06.025

Reducing perioperative blood loss with antifibrinolytics and antifibrinolytic-like agents for patients undergoing total hip and total knee arthroplasty

Bhaveen H. Kapadia, Barrett B. Torre, Nicholas Ullman, Andrew Yang, Matthew A. Harb, Preston W. Grieco, Jared M. Newman, Steven F. Harwin, Aditya V. Maheshwari

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Total hip and knee arthroplasties may be associated with a significant amount of perioperative blood loss. The severity of blood loss may be great enough to require the use of blood transfusions to treat perioperative anemia. Various methods of blood preservation have been studied. The use of antifibrinolytics and antifibrinolytic-like agents to reduce perioperative bleeding has been researched in orthopaedics and other surgical subspecialties. This review aims to evaluate the current evidence supporting the use of tranexamic acid, aminocaproic acid, fibrin tissue adhesive, and aprotinin in the reduction of perioperative blood loss in total hip and knee arthroplasties.

Original language	English
Pages (from-to)	513-516
Number of pages	4
Journal	Journal of Orthopaedics
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.jor.2019.06.025
State	Published - 1 Nov 2019

Keywords

Aminocaproic acid
Antifibrinolytic
Aprotinin
Fibrin tissue adhesive
Total joint arthroplasty
Tranexamic acid

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10.1016/j.jor.2019.06.025

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Kapadia, B. H., Torre, B. B., Ullman, N., Yang, A., Harb, M. A., Grieco, P. W., Newman, J. M., Harwin, S. F., & Maheshwari, A. V. (2019). Reducing perioperative blood loss with antifibrinolytics and antifibrinolytic-like agents for patients undergoing total hip and total knee arthroplasty. Journal of Orthopaedics, 16(6), 513-516. https://doi.org/10.1016/j.jor.2019.06.025

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title = "Reducing perioperative blood loss with antifibrinolytics and antifibrinolytic-like agents for patients undergoing total hip and total knee arthroplasty",

abstract = "Total hip and knee arthroplasties may be associated with a significant amount of perioperative blood loss. The severity of blood loss may be great enough to require the use of blood transfusions to treat perioperative anemia. Various methods of blood preservation have been studied. The use of antifibrinolytics and antifibrinolytic-like agents to reduce perioperative bleeding has been researched in orthopaedics and other surgical subspecialties. This review aims to evaluate the current evidence supporting the use of tranexamic acid, aminocaproic acid, fibrin tissue adhesive, and aprotinin in the reduction of perioperative blood loss in total hip and knee arthroplasties.",

keywords = "Aminocaproic acid, Antifibrinolytic, Aprotinin, Fibrin tissue adhesive, Total joint arthroplasty, Tranexamic acid",

author = "Kapadia, {Bhaveen H.} and Torre, {Barrett B.} and Nicholas Ullman and Andrew Yang and Harb, {Matthew A.} and Grieco, {Preston W.} and Newman, {Jared M.} and Harwin, {Steven F.} and Maheshwari, {Aditya V.}",

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AU - Kapadia, Bhaveen H.

AU - Torre, Barrett B.

AU - Ullman, Nicholas

AU - Yang, Andrew

AU - Harb, Matthew A.

AU - Grieco, Preston W.

AU - Newman, Jared M.

AU - Harwin, Steven F.

AU - Maheshwari, Aditya V.

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AB - Total hip and knee arthroplasties may be associated with a significant amount of perioperative blood loss. The severity of blood loss may be great enough to require the use of blood transfusions to treat perioperative anemia. Various methods of blood preservation have been studied. The use of antifibrinolytics and antifibrinolytic-like agents to reduce perioperative bleeding has been researched in orthopaedics and other surgical subspecialties. This review aims to evaluate the current evidence supporting the use of tranexamic acid, aminocaproic acid, fibrin tissue adhesive, and aprotinin in the reduction of perioperative blood loss in total hip and knee arthroplasties.

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KW - Antifibrinolytic

KW - Aprotinin

KW - Fibrin tissue adhesive

KW - Total joint arthroplasty

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JO - Journal of Orthopaedics

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ER -

Reducing perioperative blood loss with antifibrinolytics and antifibrinolytic-like agents for patients undergoing total hip and total knee arthroplasty

Abstract

Keywords

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