Reduced thrombogenicity of type VI collagen as compared to type I collagen

Maurizio Zangari; Karen L. Kaplan; Robert W. Glanville; Jacob H. Rand

doi:10.1016/0049-3848(95)00133-C

Reduced thrombogenicity of type VI collagen as compared to type I collagen

Maurizio Zangari, Karen L. Kaplan, Robert W. Glanville, Jacob H. Rand

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Type VI collagen has been recently identified as a major constituent of vascular subendothelium where it serves as a binding site for von Willebrand factor. The present study compares the functional characteristics of type VI collagen with those of type I collagen with respect to platelet aggregating and secretory activities. The differences between the two collagens in platelet aggregation and serotonin and betathromboglobulin release were found to be highly significant (p<0.001,p<0.0007, p<0.005 respectively). Our results indicate that under in vitro conditions, type VI collagen stimulates a significantly lesser platelet activation and aggregation response than collagen I, suggesting that type VI collagen may play a role in vivo to limit the platelet thrombotic response following injury to the vascular subendothelium.

Original language	English
Pages (from-to)	429-436
Number of pages	8
Journal	Thrombosis Research
Volume	79
Issue number	5-6
DOIs	https://doi.org/10.1016/0049-3848(95)00133-C
State	Published - 15 Sep 1995

Keywords

Collagen I
VI
activation
platelet aggregation

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10.1016/0049-3848(95)00133-C

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title = "Reduced thrombogenicity of type VI collagen as compared to type I collagen",

abstract = "Type VI collagen has been recently identified as a major constituent of vascular subendothelium where it serves as a binding site for von Willebrand factor. The present study compares the functional characteristics of type VI collagen with those of type I collagen with respect to platelet aggregating and secretory activities. The differences between the two collagens in platelet aggregation and serotonin and betathromboglobulin release were found to be highly significant (p<0.001,p<0.0007, p<0.005 respectively). Our results indicate that under in vitro conditions, type VI collagen stimulates a significantly lesser platelet activation and aggregation response than collagen I, suggesting that type VI collagen may play a role in vivo to limit the platelet thrombotic response following injury to the vascular subendothelium.",

keywords = "Collagen I, VI, activation, platelet aggregation",

author = "Maurizio Zangari and Kaplan, \{Karen L.\} and Glanville, \{Robert W.\} and Rand, \{Jacob H.\}",

note = "Funding Information: This work was supported in part by National Institute of Health grant HL-32200 and a grant from Shriners Hospital for Crippled Children. We wish to thank Nayana Pate1 and Mayra Lema for technical assistance and Charlie Gonzalez for secretarial assistance.",

year = "1995",

month = sep,

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doi = "10.1016/0049-3848(95)00133-C",

language = "English",

volume = "79",

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journal = "Thrombosis Research",

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publisher = "Elsevier Ltd.",

number = "5-6",

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TY - JOUR

T1 - Reduced thrombogenicity of type VI collagen as compared to type I collagen

AU - Zangari, Maurizio

AU - Kaplan, Karen L.

AU - Glanville, Robert W.

AU - Rand, Jacob H.

N1 - Funding Information: This work was supported in part by National Institute of Health grant HL-32200 and a grant from Shriners Hospital for Crippled Children. We wish to thank Nayana Pate1 and Mayra Lema for technical assistance and Charlie Gonzalez for secretarial assistance.

PY - 1995/9/15

Y1 - 1995/9/15

N2 - Type VI collagen has been recently identified as a major constituent of vascular subendothelium where it serves as a binding site for von Willebrand factor. The present study compares the functional characteristics of type VI collagen with those of type I collagen with respect to platelet aggregating and secretory activities. The differences between the two collagens in platelet aggregation and serotonin and betathromboglobulin release were found to be highly significant (p<0.001,p<0.0007, p<0.005 respectively). Our results indicate that under in vitro conditions, type VI collagen stimulates a significantly lesser platelet activation and aggregation response than collagen I, suggesting that type VI collagen may play a role in vivo to limit the platelet thrombotic response following injury to the vascular subendothelium.

AB - Type VI collagen has been recently identified as a major constituent of vascular subendothelium where it serves as a binding site for von Willebrand factor. The present study compares the functional characteristics of type VI collagen with those of type I collagen with respect to platelet aggregating and secretory activities. The differences between the two collagens in platelet aggregation and serotonin and betathromboglobulin release were found to be highly significant (p<0.001,p<0.0007, p<0.005 respectively). Our results indicate that under in vitro conditions, type VI collagen stimulates a significantly lesser platelet activation and aggregation response than collagen I, suggesting that type VI collagen may play a role in vivo to limit the platelet thrombotic response following injury to the vascular subendothelium.

KW - Collagen I

KW - VI

KW - activation

KW - platelet aggregation

UR - https://www.scopus.com/pages/publications/0029128026

U2 - 10.1016/0049-3848(95)00133-C

DO - 10.1016/0049-3848(95)00133-C

M3 - Article

C2 - 7502269

AN - SCOPUS:0029128026

SN - 0049-3848

VL - 79

SP - 429

EP - 436

JO - Thrombosis Research

JF - Thrombosis Research

IS - 5-6

ER -

Reduced thrombogenicity of type VI collagen as compared to type I collagen

Abstract

Keywords

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