Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism

Maria T. Lazaro; Jiannis Taxidis; Tristan Shuman; Iris Bachmutsky; Taruna Ikrar; Rommel Santos; G. Mark Marcello; Apoorva Mylavarapu; Swasty Chandra; Allison Foreman; Rachna Goli; Duy Tran; Nikhil Sharma; Michelle Azhdam; Hongmei Dong; Katrina Y. Choe; Olga Peñagarikano; Sotiris C. Masmanidis; Bence Rácz; Xiangmin Xu; Daniel H. Geschwind; Peyman Golshani

doi:10.1016/j.celrep.2019.05.006

Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism

Maria T. Lazaro, Jiannis Taxidis, Tristan Shuman, Iris Bachmutsky, Taruna Ikrar, Rommel Santos, G. Mark Marcello, Apoorva Mylavarapu, Swasty Chandra, Allison Foreman, Rachna Goli, Duy Tran, Nikhil Sharma, Michelle Azhdam, Hongmei Dong, Katrina Y. Choe, Olga Peñagarikano, Sotiris C. Masmanidis, Bence Rácz, Xiangmin XuDaniel H. Geschwind, Peyman Golshani

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71 Scopus citations

Abstract

Lazaro et al. demonstrate a decrease in synaptic inputs onto mPFC L2/3 pyramidal neurons of Cntnap2 KO mice, concurrent with reduced spines and synapses. These lead to perturbed network activity, with mPFC cells exhibiting reduced phase locking and altered preferred phases to slow LFP oscillations, which may underlie autism-related phenotypes.

Original language	English
Pages (from-to)	2567-2578.e6
Journal	Cell Reports
Volume	27
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2019.05.006
State	Published - 28 May 2019

Keywords

EEG
biomarker
brain state
connectivity
delta
functional
inhibition
oscillation
phase-locking
theta

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10.1016/j.celrep.2019.05.006

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Lazaro, M. T., Taxidis, J., Shuman, T., Bachmutsky, I., Ikrar, T., Santos, R., Marcello, G. M., Mylavarapu, A., Chandra, S., Foreman, A., Goli, R., Tran, D., Sharma, N., Azhdam, M., Dong, H., Choe, K. Y., Peñagarikano, O., Masmanidis, S. C., Rácz, B., ... Golshani, P. (2019). Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism. Cell Reports, 27(9), 2567-2578.e6. https://doi.org/10.1016/j.celrep.2019.05.006

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title = "Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism",

abstract = "Lazaro et al. demonstrate a decrease in synaptic inputs onto mPFC L2/3 pyramidal neurons of Cntnap2 KO mice, concurrent with reduced spines and synapses. These lead to perturbed network activity, with mPFC cells exhibiting reduced phase locking and altered preferred phases to slow LFP oscillations, which may underlie autism-related phenotypes.",

keywords = "EEG, biomarker, brain state, connectivity, delta, functional, inhibition, oscillation, phase-locking, theta",

author = "Lazaro, {Maria T.} and Jiannis Taxidis and Tristan Shuman and Iris Bachmutsky and Taruna Ikrar and Rommel Santos and Marcello, {G. Mark} and Apoorva Mylavarapu and Swasty Chandra and Allison Foreman and Rachna Goli and Duy Tran and Nikhil Sharma and Michelle Azhdam and Hongmei Dong and Choe, {Katrina Y.} and Olga Pe{\~n}agarikano and Masmanidis, {Sotiris C.} and Bence R{\'a}cz and Xiangmin Xu and Geschwind, {Daniel H.} and Peyman Golshani",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = may,

day = "28",

doi = "10.1016/j.celrep.2019.05.006",

language = "English",

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pages = "2567--2578.e6",

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Lazaro, MT, Taxidis, J, Shuman, T, Bachmutsky, I, Ikrar, T, Santos, R, Marcello, GM, Mylavarapu, A, Chandra, S, Foreman, A, Goli, R, Tran, D, Sharma, N, Azhdam, M, Dong, H, Choe, KY, Peñagarikano, O, Masmanidis, SC, Rácz, B, Xu, X, Geschwind, DH & Golshani, P 2019, 'Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism', Cell Reports, vol. 27, no. 9, pp. 2567-2578.e6. https://doi.org/10.1016/j.celrep.2019.05.006

TY - JOUR

T1 - Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism

AU - Lazaro, Maria T.

AU - Taxidis, Jiannis

AU - Shuman, Tristan

AU - Bachmutsky, Iris

AU - Ikrar, Taruna

AU - Santos, Rommel

AU - Marcello, G. Mark

AU - Mylavarapu, Apoorva

AU - Chandra, Swasty

AU - Foreman, Allison

AU - Goli, Rachna

AU - Tran, Duy

AU - Sharma, Nikhil

AU - Azhdam, Michelle

AU - Dong, Hongmei

AU - Choe, Katrina Y.

AU - Peñagarikano, Olga

AU - Masmanidis, Sotiris C.

AU - Rácz, Bence

AU - Xu, Xiangmin

AU - Geschwind, Daniel H.

AU - Golshani, Peyman

PY - 2019/5/28

Y1 - 2019/5/28

N2 - Lazaro et al. demonstrate a decrease in synaptic inputs onto mPFC L2/3 pyramidal neurons of Cntnap2 KO mice, concurrent with reduced spines and synapses. These lead to perturbed network activity, with mPFC cells exhibiting reduced phase locking and altered preferred phases to slow LFP oscillations, which may underlie autism-related phenotypes.

AB - Lazaro et al. demonstrate a decrease in synaptic inputs onto mPFC L2/3 pyramidal neurons of Cntnap2 KO mice, concurrent with reduced spines and synapses. These lead to perturbed network activity, with mPFC cells exhibiting reduced phase locking and altered preferred phases to slow LFP oscillations, which may underlie autism-related phenotypes.

KW - EEG

KW - biomarker

KW - brain state

KW - connectivity

KW - delta

KW - functional

KW - inhibition

KW - oscillation

KW - phase-locking

KW - theta

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DO - 10.1016/j.celrep.2019.05.006

M3 - Article

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AN - SCOPUS:85065896533

SN - 2211-1247

VL - 27

SP - 2567-2578.e6

JO - Cell Reports

JF - Cell Reports

IS - 9

ER -

Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism

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Keywords

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