Reduced neuropeptide Y mRNA expression in the prefrontal cortex of subjects with bipolar disorder

Laura Caberlotto, Yasmin L. Hurd

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

In the present study, we compared neuropeptide Y mRNA expression levels in the prefrontal cortex (Brodmann area 9 and 46) of subjects diagnosed with major depression, bipolar disorder and schizophrenia with those in normal controls without a psychiatric history. No correlation was found regarding neuropeptide Y mRNA expression and postmortem interval, age, gender, hemisphere side, suicide as cause of death, or the history of use of substances such as alcohol, marihuana and cocaine/amphetamine. The only significant alteration found was related to the clinical diagnosis; neuropeptide Y mRNA expression was reduced in the group of bipolar subjects as compared to the controls. Overall, the present results confirm an involvement of neuropeptide Y in affective disorders, and show for the first time a specific association between NPY and bipolar disorder.

Original languageEnglish
Pages (from-to)1747-1750
Number of pages4
JournalNeuroReport
Volume10
Issue number8
DOIs
StatePublished - 3 Jun 1999
Externally publishedYes

Keywords

  • Affective disorders
  • In situ hybridization
  • Major depression
  • Neuropeptide Y
  • Schizophrenia

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