Reduced myocardial blood flow during left ventricular assist device support: A possible cause of premature bypass graft closure

Steve Xydas; Rebecca S. Rosen; Sean Pinney; Kathleen T. Hickey; Hal Wasserman; Donna M. Mancini; Yoshifumi Naka; Mehmet C. Oz; Steven R. Bergmann; Simon Maybaum

doi:10.1016/j.healun.2005.03.003

Reduced myocardial blood flow during left ventricular assist device support: A possible cause of premature bypass graft closure

Steve Xydas, Rebecca S. Rosen, Sean Pinney, Kathleen T. Hickey, Hal Wasserman, Donna M. Mancini, Yoshifumi Naka, Mehmet C. Oz, Steven R. Bergmann, Simon Maybaum

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Our aim was to determine the effect of left ventricular assist device (LVAD) implantation on bypass graft patency and to measure myocardial oxygen consumption (MVO₂) and blood flow during LVAD support. Five patients who underwent coronary artery bypass grafting and required LVAD implantation for post-cardiotomy cardiogenic shock had coronary angiography during device support to assess graft patency. Positron emission tomography measurements were made in a separate cohort of LVAD patients with dilated cardiomyopathy to assess the effects of LVAD support on MVO₂ and myocardial blood flow. In this small series, LVAD unloading led to a high rate of premature graft occlusion in post-cardiotomy cardiogenic shock patients supported with a device; whereas, positron emission tomography measurements showed significantly reduced MVO₂ and myocardial flood flow in dilated cardiomyopathy patients supported with an LVAD, compared with healthy subjects. Reduced myocardial blood flow may be implicated in the premature graft failure observed in post-cardiotomy cardiogenic shock patients and may negatively impact the potential for myocardial recovery and device weaning in this population.

Original language	English
Pages (from-to)	1976-1979
Number of pages	4
Journal	Journal of Heart and Lung Transplantation
Volume	24
Issue number	11
DOIs	https://doi.org/10.1016/j.healun.2005.03.003
State	Published - Nov 2005
Externally published	Yes

Access to Document

10.1016/j.healun.2005.03.003

Cite this

Xydas, S., Rosen, R. S., Pinney, S., Hickey, K. T., Wasserman, H., Mancini, D. M., Naka, Y., Oz, M. C., Bergmann, S. R., & Maybaum, S. (2005). Reduced myocardial blood flow during left ventricular assist device support: A possible cause of premature bypass graft closure. Journal of Heart and Lung Transplantation, 24(11), 1976-1979. https://doi.org/10.1016/j.healun.2005.03.003

@article{13bcdde296034174b80704a51801277f,

title = "Reduced myocardial blood flow during left ventricular assist device support: A possible cause of premature bypass graft closure",

abstract = "Our aim was to determine the effect of left ventricular assist device (LVAD) implantation on bypass graft patency and to measure myocardial oxygen consumption (MVO2) and blood flow during LVAD support. Five patients who underwent coronary artery bypass grafting and required LVAD implantation for post-cardiotomy cardiogenic shock had coronary angiography during device support to assess graft patency. Positron emission tomography measurements were made in a separate cohort of LVAD patients with dilated cardiomyopathy to assess the effects of LVAD support on MVO2 and myocardial blood flow. In this small series, LVAD unloading led to a high rate of premature graft occlusion in post-cardiotomy cardiogenic shock patients supported with a device; whereas, positron emission tomography measurements showed significantly reduced MVO2 and myocardial flood flow in dilated cardiomyopathy patients supported with an LVAD, compared with healthy subjects. Reduced myocardial blood flow may be implicated in the premature graft failure observed in post-cardiotomy cardiogenic shock patients and may negatively impact the potential for myocardial recovery and device weaning in this population.",

author = "Steve Xydas and Rosen, {Rebecca S.} and Sean Pinney and Hickey, {Kathleen T.} and Hal Wasserman and Mancini, {Donna M.} and Yoshifumi Naka and Oz, {Mehmet C.} and Bergmann, {Steven R.} and Simon Maybaum",

year = "2005",

month = nov,

doi = "10.1016/j.healun.2005.03.003",

language = "English",

volume = "24",

pages = "1976--1979",

journal = "Journal of Heart and Lung Transplantation",

issn = "1053-2498",

publisher = "Elsevier Inc.",

number = "11",

}

Xydas, S, Rosen, RS, Pinney, S, Hickey, KT, Wasserman, H, Mancini, DM, Naka, Y, Oz, MC, Bergmann, SR & Maybaum, S 2005, 'Reduced myocardial blood flow during left ventricular assist device support: A possible cause of premature bypass graft closure', Journal of Heart and Lung Transplantation, vol. 24, no. 11, pp. 1976-1979. https://doi.org/10.1016/j.healun.2005.03.003

TY - JOUR

T1 - Reduced myocardial blood flow during left ventricular assist device support

T2 - A possible cause of premature bypass graft closure

AU - Xydas, Steve

AU - Rosen, Rebecca S.

AU - Pinney, Sean

AU - Hickey, Kathleen T.

AU - Wasserman, Hal

AU - Mancini, Donna M.

AU - Naka, Yoshifumi

AU - Oz, Mehmet C.

AU - Bergmann, Steven R.

AU - Maybaum, Simon

PY - 2005/11

Y1 - 2005/11

N2 - Our aim was to determine the effect of left ventricular assist device (LVAD) implantation on bypass graft patency and to measure myocardial oxygen consumption (MVO2) and blood flow during LVAD support. Five patients who underwent coronary artery bypass grafting and required LVAD implantation for post-cardiotomy cardiogenic shock had coronary angiography during device support to assess graft patency. Positron emission tomography measurements were made in a separate cohort of LVAD patients with dilated cardiomyopathy to assess the effects of LVAD support on MVO2 and myocardial blood flow. In this small series, LVAD unloading led to a high rate of premature graft occlusion in post-cardiotomy cardiogenic shock patients supported with a device; whereas, positron emission tomography measurements showed significantly reduced MVO2 and myocardial flood flow in dilated cardiomyopathy patients supported with an LVAD, compared with healthy subjects. Reduced myocardial blood flow may be implicated in the premature graft failure observed in post-cardiotomy cardiogenic shock patients and may negatively impact the potential for myocardial recovery and device weaning in this population.

AB - Our aim was to determine the effect of left ventricular assist device (LVAD) implantation on bypass graft patency and to measure myocardial oxygen consumption (MVO2) and blood flow during LVAD support. Five patients who underwent coronary artery bypass grafting and required LVAD implantation for post-cardiotomy cardiogenic shock had coronary angiography during device support to assess graft patency. Positron emission tomography measurements were made in a separate cohort of LVAD patients with dilated cardiomyopathy to assess the effects of LVAD support on MVO2 and myocardial blood flow. In this small series, LVAD unloading led to a high rate of premature graft occlusion in post-cardiotomy cardiogenic shock patients supported with a device; whereas, positron emission tomography measurements showed significantly reduced MVO2 and myocardial flood flow in dilated cardiomyopathy patients supported with an LVAD, compared with healthy subjects. Reduced myocardial blood flow may be implicated in the premature graft failure observed in post-cardiotomy cardiogenic shock patients and may negatively impact the potential for myocardial recovery and device weaning in this population.

UR - http://www.scopus.com/inward/record.url?scp=27844506165&partnerID=8YFLogxK

U2 - 10.1016/j.healun.2005.03.003

DO - 10.1016/j.healun.2005.03.003

M3 - Article

C2 - 16297808

AN - SCOPUS:27844506165

SN - 1053-2498

VL - 24

SP - 1976

EP - 1979

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

IS - 11

ER -

Reduced myocardial blood flow during left ventricular assist device support: A possible cause of premature bypass graft closure

Abstract

Access to Document

Fingerprint

Cite this