TY - JOUR
T1 - Reduced cortical thickness in World Trade Center responders with cognitive impairment
AU - Clouston, Sean A.P.
AU - Deri, Yael
AU - Horton, Megan
AU - Tang, Cheuk
AU - Diminich, Erica
AU - DeLorenzo, Christine
AU - Kritikos, Minos
AU - Pellecchia, Alison C.
AU - Santiago-Michels, Stephanie
AU - Carr, Melissa A.
AU - Gandy, Samuel
AU - Sano, Mary
AU - Bromet, Evelyn J.
AU - Lucchini, Roberto G.
AU - Luft, Benjamin J.
N1 - Funding Information:
The authors would like to acknowledge support from the Centers for Disease Control and Prevention for supporting the neuroimaging study (CDC/NIOSH U01 OH011314), the National Institute on Aging that supports research on characterization and treatment of Alzheimer's disease (NIH/NIA P50 AG005138), and aging-related work in this population (NIH/NIA R01 AG049953). We would also like to acknowledge ongoing funding to monitor World Trade Center responders as part of the WTC Health and Wellness Program (CDC 200-2011-39361).
Funding Information:
The authors would like to acknowledge support from the Centers for Disease Control and Prevention for supporting the neuroimaging study (CDC/NIOSH U01 OH011314), the National Institute on Aging that supports research on characterization and treatment of Alzheimer's disease (NIH/NIA P50 AG005138), and aging‐related work in this population (NIH/NIA R01 AG049953). We would also like to acknowledge ongoing funding to monitor World Trade Center responders as part of the WTC Health and Wellness Program (CDC 200‐2011‐39361).
Publisher Copyright:
© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association
PY - 2020
Y1 - 2020
N2 - Introduction: This study examined cortical thickness (CTX) in World Trade Center (WTC) responders with cognitive impairment (CI). Methods: WTC responders (N = 99) with/without CI, recruited from an epidemiologic study, completed a T1-MPRAGE protocol. CTX was automatically computed in 34 regions of interest. Region-based and surface-based morphometry examined CTX in CI versus unimpaired responders. CTX was automatically computed in 34 regions of interest. Region-based measures were also compared to published norms. Results: Participants were 55.8 (SD = 0.52) years old; 48 had CI. Compared to unimpaired responders, global mean CTX was reduced in CI and across 21/34 cortical subregions. Surface-based analyses revealed reduced CTX across frontal, temporal, and parietal lobes when adjusting for multiple comparisons. Both CI and unimpaired WTC groups had reduced CTX in the entorhinal and temporal cortices compared to published normative data. Discussion: Results from the first structural magnetic resonance imaging study in WTC responders identified reduced CTX consistent with a neurodegenerative disease of unknown etiology.
AB - Introduction: This study examined cortical thickness (CTX) in World Trade Center (WTC) responders with cognitive impairment (CI). Methods: WTC responders (N = 99) with/without CI, recruited from an epidemiologic study, completed a T1-MPRAGE protocol. CTX was automatically computed in 34 regions of interest. Region-based and surface-based morphometry examined CTX in CI versus unimpaired responders. CTX was automatically computed in 34 regions of interest. Region-based measures were also compared to published norms. Results: Participants were 55.8 (SD = 0.52) years old; 48 had CI. Compared to unimpaired responders, global mean CTX was reduced in CI and across 21/34 cortical subregions. Surface-based analyses revealed reduced CTX across frontal, temporal, and parietal lobes when adjusting for multiple comparisons. Both CI and unimpaired WTC groups had reduced CTX in the entorhinal and temporal cortices compared to published normative data. Discussion: Results from the first structural magnetic resonance imaging study in WTC responders identified reduced CTX consistent with a neurodegenerative disease of unknown etiology.
KW - World Trade Center responders
KW - cognitive impairment
KW - cortical thickness
UR - http://www.scopus.com/inward/record.url?scp=85097184494&partnerID=8YFLogxK
U2 - 10.1002/dad2.12059
DO - 10.1002/dad2.12059
M3 - Article
AN - SCOPUS:85097184494
SN - 2352-8729
VL - 12
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IS - 1
M1 - e12059
ER -