Redefining actin dynamics of the pointed-end complex in striated muscle

Jessika Iwanski; Carol C. Gregorio; Mert Colpan

doi:10.1016/j.tcb.2021.06.006

Redefining actin dynamics of the pointed-end complex in striated muscle

Jessika Iwanski
, Carol C. Gregorio
, Mert Colpan

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

Striated muscle is intricately designed to provide efficient and powerful muscle contractions. Recently, a long sought-after missing component of the thin filament pointed-end machinery was discovered: cyclase-associated protein 2 (CAP2). CAP2 was identified as a crucial contributor to actin polymerization, striated muscle development, and severe muscle disease when mutated.

Original language	English
Pages (from-to)	708-711
Number of pages	4
Journal	Trends in Cell Biology
Volume	31
Issue number	9
DOIs	https://doi.org/10.1016/j.tcb.2021.06.006
State	Published - Sep 2021
Externally published	Yes

Keywords

actin
muscle
myopathy
sarcomere
thin filament

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10.1016/j.tcb.2021.06.006

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title = "Redefining actin dynamics of the pointed-end complex in striated muscle",

abstract = "Striated muscle is intricately designed to provide efficient and powerful muscle contractions. Recently, a long sought-after missing component of the thin filament pointed-end machinery was discovered: cyclase-associated protein 2 (CAP2). CAP2 was identified as a crucial contributor to actin polymerization, striated muscle development, and severe muscle disease when mutated.",

keywords = "actin, muscle, myopathy, sarcomere, thin filament",

author = "Jessika Iwanski and Gregorio, \{Carol C.\} and Mert Colpan",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

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doi = "10.1016/j.tcb.2021.06.006",

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AU - Iwanski, Jessika

AU - Gregorio, Carol C.

AU - Colpan, Mert

PY - 2021/9

Y1 - 2021/9

N2 - Striated muscle is intricately designed to provide efficient and powerful muscle contractions. Recently, a long sought-after missing component of the thin filament pointed-end machinery was discovered: cyclase-associated protein 2 (CAP2). CAP2 was identified as a crucial contributor to actin polymerization, striated muscle development, and severe muscle disease when mutated.

AB - Striated muscle is intricately designed to provide efficient and powerful muscle contractions. Recently, a long sought-after missing component of the thin filament pointed-end machinery was discovered: cyclase-associated protein 2 (CAP2). CAP2 was identified as a crucial contributor to actin polymerization, striated muscle development, and severe muscle disease when mutated.

KW - actin

KW - muscle

KW - myopathy

KW - sarcomere

KW - thin filament

UR - https://www.scopus.com/pages/publications/85110389973

U2 - 10.1016/j.tcb.2021.06.006

DO - 10.1016/j.tcb.2021.06.006

M3 - Short survey

C2 - 34266732

AN - SCOPUS:85110389973

SN - 0962-8924

VL - 31

SP - 708

EP - 711

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 9

ER -

Redefining actin dynamics of the pointed-end complex in striated muscle

Abstract

Keywords

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