Red Blood Cells from Stem Cells

Anna Rita Migliaccio, Carolyn Whitsett, Giovanni Migliaccio

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations
Original languageEnglish
Title of host publicationChemistry and Biochemistry of Oxygen Therapeutics
Subtitle of host publicationFrom Transfusion to Artificial Blood
PublisherJohn Wiley and Sons
Pages257-271
Number of pages15
ISBN (Print)9780470686683
DOIs
StatePublished - 4 Jul 2011

Keywords

  • Alternative sources of stem cells - properties of ex vivo-generated erythroid cells
  • Biomarkers, monitoring EB expansion - in production
  • Hypothetical ex vivo red cell production process anatomy
  • Model for mechanism of action of GR and ESR - on erythroid maturation, transcription factor GATA1
  • Red blood cells - from stem cells
  • Red cells, cellular elements of blood - oxygen delivery, tissues of body
  • Safety concerns, for cell therapy - product exposure, xenogeneic substances
  • Specific growth factors (GFs) - pluripotent hemopoietic stem cells (HSCs), and EPCs
  • Stem-cell sources for ex vivo generation - of erythroid cells, as transfusion product
  • ex vivo-expanded EBs for alloimmunized patients - alloimmunization, in multitransfused patients

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