TY - JOUR
T1 - Red blood cell choline. II
T2 - Kinetics in alzheimer's disease
AU - Kanof, Philip D.
AU - Greenwald, Blaine S.
AU - Mohs, Richard C.
AU - Davis, Kenneth L.
N1 - Funding Information:
From the Department of Psychiatry, Bronx VA Medical Center, Bronx, NY (P.D.K., B.S.G., R.C.M., K.L.D.), and the DeparUnent of Psychiauy (P.D.K., B.S.G., R.C.M., K.L.D.), and the Dei~tment of Pharmacology CK.L.D.), Mt. Sinai School of Medicine, New York, N'Y. This work was supported by a grant from the National Institute of Aging, NIMH, and a Medical Research Service Grant from the Veterans Administration. Address reprint requests to Dr. Phifip D. Kanof, Psychiauy Service, Bronx VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468. Received April 25, 1984; revised September 10, 1984.
PY - 1985/4
Y1 - 1985/4
N2 - The kinetic parameters of choline uptake into red blood cells from patients with Alzheimer's disease and normal elderly controls were compared. The Kd and Vmax values for choline uptake into red cells were determined based on a kinetic analysis of choline uptake at six different concentrations of labeled extracellular choline. The theoretical choline uptake, representing the initial rate of choline influx into choline-depleted red cells given the plasma choline concentration and the kinetic parameters of choline uptake, was also calculated. Alzheimer's disease patients and normal controls did not differ in any kinetic parameter of choline uptake. Kd and Vmax values for red cell choline uptake were strongly correlated among normal controls, but not among patients with Alzheimer's disease. In addition, among the patients with Alzheimer's disease, the theoretical choline uptake was strongly correlated with the severity of dementia. The possible significance of these findings in relation to altered choline metabolism in Alzheimer's disease is discussed.
AB - The kinetic parameters of choline uptake into red blood cells from patients with Alzheimer's disease and normal elderly controls were compared. The Kd and Vmax values for choline uptake into red cells were determined based on a kinetic analysis of choline uptake at six different concentrations of labeled extracellular choline. The theoretical choline uptake, representing the initial rate of choline influx into choline-depleted red cells given the plasma choline concentration and the kinetic parameters of choline uptake, was also calculated. Alzheimer's disease patients and normal controls did not differ in any kinetic parameter of choline uptake. Kd and Vmax values for red cell choline uptake were strongly correlated among normal controls, but not among patients with Alzheimer's disease. In addition, among the patients with Alzheimer's disease, the theoretical choline uptake was strongly correlated with the severity of dementia. The possible significance of these findings in relation to altered choline metabolism in Alzheimer's disease is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0022193328&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(85)90040-X
DO - 10.1016/0006-3223(85)90040-X
M3 - Article
C2 - 3978171
AN - SCOPUS:0022193328
SN - 0006-3223
VL - 20
SP - 375
EP - 383
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 4
ER -