Recurring fibro-obliterative venopathy in liver allografts

M. Isabel Fiel, Thomas D. Schiano, Franklin M. Klion, Sukru Emre, Prodromes Hytiroglou, Kamal G. Ishak, Arief Suriawinata, Swan N. Thung

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Recurrent diseases in liver allografts are not uncommon. These occur most frequently in those transplanted for viral hepatitis B and C. We report an unusual case of recurrent process in two consecutive liver allografts received by a 37-year-old woman, who previously had an unremarkable past medical history but developed a rapidly progressive cholestatic liver failure. Histopathologic examination of the native liver showed fibroocclusive lesions of both terminal hepatic venules and portal vein branches. The exuberant fibroobliterative process created dense fibrosis with whorled appearance, and broad fibrous septa connecting adjacent central areas, and sometimes bridging portal to central areas. Dense portal fibrosis resulted in compression atrophy and loss of bile ducts. The first allograft, which failed within 3 months, showed histopathologic findings similar to that of the native liver. A liver biopsy that was performed 20 months after the second liver transplant again showed similar histopathology. The histopathologic features and clinical presentation of this patient suggest an unusual form of recurring progressive fibroobliterative venopathy causing liver failure.

Original languageEnglish
Pages (from-to)734-737
Number of pages4
JournalAmerican Journal of Surgical Pathology
Volume23
Issue number6
DOIs
StatePublished - Jun 1999

Keywords

  • Disease recurrence
  • Liver transplant
  • Sclerosing cholangitis
  • Venopathy

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