TY - JOUR
T1 - Recurring chromosomal abnormalities in Non-Hodgkin's lymphoma
T2 - Biologic and clinical significance
AU - Chaganti, R. S.K.
AU - Nanjangud, Gouri
AU - Schmidt, Helmut
AU - Julie, Teruya Feldstein
N1 - Funding Information:
ON-HODGKIN’S lymphoma (NHL) is among N the four most important causeso f person-years of life lost in the US population, and its incidence has been rising.l o7NHLs arisei n cellsu ndergoing Band T-lymphoid lineage differentiation and present complex histologic and immunologic phenotypes. As a result, their biology has been difficult to understand and their classificationi nto biologically or clinically meaningful subsetsh ard to accomplish.O ver the past two decades,s everals ystemso f lymphoma classification have been devised,m ost recently by the World Health Organization (WHO) !2 The WHO classification recognizes three main groups (with multiple subsets)N: HL of B cells and T/natural killer (NK) cells and Hodgkin’s diseaseT. he emphasiso f these classificatione fforts has been to relate the morpho- From the Cell Biology Program and the Departmenti of Human Genetics and Patbologlr Memorial Sloan-Kettering Cancer Center, Nao York, NY Supported by National Institutes of Health Grants No. LX34775 and CA66999 to R.S.K C. and Austrtin ScienceF und Grant No. P-1692-MED to HS. Address reprint requests to R.S.K Cbaganti, PbD, Memorial Sloan-Ketteting Cancer Center, I275 York Ave, New Y,rk, NY 10021. Copyright 0 2000 by WB. Saunders Company 0037-1963/00/3704-0008$10.00/0 doi:10.1053hbem.2000.16448 logic, immunologic, and clinical tumor phenotypest o the stage in lineage development of the putative precursor cell on the one hand, and to clinical endpoints such as responseto treatment and patient survival on the other. Among NHLs, B-lineage tumors compriseg reatert han TO%, while T-cell/NK-cell lymphomas make up the rest.41,42 Genetic analysis is perhaps the most powerful meanst o resolve the biologic complexity of tumors and to gain insights into their clinical behavior. This approach involves conventional cytogenetic analysis by G-banding and molecular cytogenetic analysisb y fluorescencei n situ hybridization (FISH), chromo-somep ainting, multicolor spectrakl aryotyping (SKY), and comparative genomic hybridization (CGH). Information gained horn cytogenetic analysesa re used to direct molecularg enetic studiesa imed at identification and analysiso f the function of genesd eregulated, inactivated, or overexpressedin tumors. In spite of exciting advances that have taken place over the past decadea nd a half, the genetic picture of NHL is far from complete, reflecting the complicated biology and the morphologic and clinical heterogeneity of this diseaseH. ere, the genetic basiso f NHL development will be briefly discussedf,o llowed by a review of nonrandom chromosomal changesi n the different histologic subsetsa nd their clinical significance.
PY - 2000
Y1 - 2000
N2 - Non-Hodgkin's lymphomas (NHLs) are a group of clinically important neoplasms with a complex biology that makes their classification and treatment difficult. Their incidence is increasing and they cause significant morbidity and mortality. NHLs result from transformation of B and T/natural killer (NK) cells. Their genetic hallmark is chromosomal translocations resulting from aberrant rearrangements of IG and TCR genes, which lead to inappropriate expression of genes at reciprocal breakpoints that regulate a variety of cellular functions, including gene transcription, cell cycle, apoptosis, and tumor progression. Cytogenetics followed by molecular genetic analysis of some of the recurring translocations continues to provide new insights into lymphomagenesis and cell biology. More recently, chromosomal and gene amplification and gene deletion have been recognized as frequent genetic changes that may play a role in lymphoma progression and clinical behavior. In this review, cytogenetic data pertaining to recurring chromosomal changes on lymphomas are reviewed and examined in relation to their relevance to lymphoma development, classification, and clinical behavior. (C) 2000 by W.B. Saunders Company.
AB - Non-Hodgkin's lymphomas (NHLs) are a group of clinically important neoplasms with a complex biology that makes their classification and treatment difficult. Their incidence is increasing and they cause significant morbidity and mortality. NHLs result from transformation of B and T/natural killer (NK) cells. Their genetic hallmark is chromosomal translocations resulting from aberrant rearrangements of IG and TCR genes, which lead to inappropriate expression of genes at reciprocal breakpoints that regulate a variety of cellular functions, including gene transcription, cell cycle, apoptosis, and tumor progression. Cytogenetics followed by molecular genetic analysis of some of the recurring translocations continues to provide new insights into lymphomagenesis and cell biology. More recently, chromosomal and gene amplification and gene deletion have been recognized as frequent genetic changes that may play a role in lymphoma progression and clinical behavior. In this review, cytogenetic data pertaining to recurring chromosomal changes on lymphomas are reviewed and examined in relation to their relevance to lymphoma development, classification, and clinical behavior. (C) 2000 by W.B. Saunders Company.
UR - http://www.scopus.com/inward/record.url?scp=0033784294&partnerID=8YFLogxK
U2 - 10.1016/S0037-1963(00)90019-2
DO - 10.1016/S0037-1963(00)90019-2
M3 - Article
C2 - 11071361
AN - SCOPUS:0033784294
VL - 37
SP - 396
EP - 411
JO - Seminars in Hematology
JF - Seminars in Hematology
SN - 0037-1963
IS - 4
ER -