Recurrent respiratory papillomatosis

Recurrent respiratory papillomatosis (RRP) is an acquired condition resulting in the growth of exophytic, wart-like lesions anywhere in the upper aerodigestive tract. This chapter will solely focus on papillomatosis affecting the larynx, the most affected site. While RRP is a benign condition, its recurrent nature makes it a source of morbidity due to the frequent need for surgical debulking and rare potential for airway obstruction or malignant transformation. Management has evolved significantly over the last 50 years, and understanding the evidence basis for diagnostic and treatment approaches is critically important.