TY - JOUR
T1 - Recurrent Intrahepatic Cholangiocarcinoma – Review
AU - Bekki, Yuki
AU - Von Ahrens, Dagny
AU - Takahashi, Hideo
AU - Schwartz, Myron
AU - Gunasekaran, Ganesh
N1 - Publisher Copyright:
Copyright © 2021 Bekki, Von Ahrens, Takahashi, Schwartz and Gunasekaran.
PY - 2021/10/21
Y1 - 2021/10/21
N2 - Intrahepatic cholangiocarcinoma (ICC) is the second-most common primary liver malignancy after hepatocellular carcinoma. While surgical resection with negative margin is the only curative treatment, ICC has very high rate of recurrence, up to 60-70% after curative resection. We reviewed the current data available on risk factors for ICC recurrence, recurrence pattern (location and timing), treatment options, and future directions. The risk factors for recurrence include elevated preoperative CA19-9, presence of liver cirrhosis, nodal metastasis, positive margins, and vascular invasion. Understanding different recurrence patterns, timing course, and risk factors for early recurrence is important to tailor postoperative surveillance and select treatment strategies including systemic or locoregional therapy. Re-resection can be considered for a selected patient population at experienced centers, and can yield long-term survival. ICC remains a dismal disease given the high likelihood of recurrence. Advances in our understanding of the genomic landscape of ICC are beginning to identify targetable alterations in ICC in subsets of patients that allow for personalized treatment.
AB - Intrahepatic cholangiocarcinoma (ICC) is the second-most common primary liver malignancy after hepatocellular carcinoma. While surgical resection with negative margin is the only curative treatment, ICC has very high rate of recurrence, up to 60-70% after curative resection. We reviewed the current data available on risk factors for ICC recurrence, recurrence pattern (location and timing), treatment options, and future directions. The risk factors for recurrence include elevated preoperative CA19-9, presence of liver cirrhosis, nodal metastasis, positive margins, and vascular invasion. Understanding different recurrence patterns, timing course, and risk factors for early recurrence is important to tailor postoperative surveillance and select treatment strategies including systemic or locoregional therapy. Re-resection can be considered for a selected patient population at experienced centers, and can yield long-term survival. ICC remains a dismal disease given the high likelihood of recurrence. Advances in our understanding of the genomic landscape of ICC are beginning to identify targetable alterations in ICC in subsets of patients that allow for personalized treatment.
KW - intrahepatic cholangiocarcinoma
KW - management
KW - re-resection of the liver
KW - recurrence
KW - risk factors for recurrence
UR - http://www.scopus.com/inward/record.url?scp=85118658281&partnerID=8YFLogxK
U2 - 10.3389/fonc.2021.776863
DO - 10.3389/fonc.2021.776863
M3 - Review article
AN - SCOPUS:85118658281
SN - 2234-943X
VL - 11
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 776863
ER -