Recruitment and retention strategies in a clinical trial for children with chronic hepatitis c infection

Aparna Roy; Whitney Lieb; Beth Garrett; Marcia Hodik; Ann Klipsch; Melissa Young; Bruce Barton; Kathleen B. Schwarz

doi:10.1016/j.pedn.2012.08.006

Recruitment and retention strategies in a clinical trial for children with chronic hepatitis c infection

Aparna Roy, Whitney Lieb, Beth Garrett, Marcia Hodik, Ann Klipsch, Melissa Young, Bruce Barton, Kathleen B. Schwarz

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Successful strategies for recruitment and retention (R & R) in pediatric trials are needed. The purpose of our study was to analyze the effectiveness of R&R in a trial for children with hepatitis C. Recruitment strategies were (1) Initial (months 0-12) and (2) extra effort (months 13-18). Initial strategies enrolled 70/114 (61%) of patients. Extra effort strategies included: (1) radio broadcasts, (2) contact with adult hepatologists, (3) dissemination of study material and (4) modification of the exclusion criteria. The overall retention rate was 84% at 2. years. Lessons learned will be valuable in designing future pediatric trials.

Original language	English
Pages (from-to)	243-248
Number of pages	6
Journal	Journal of Pediatric Nursing
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/j.pedn.2012.08.006
State	Published - May 2013
Externally published	Yes

Keywords

Hepatitis C virus
Pediatric clinical trials
Recruitment
Retention

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10.1016/j.pedn.2012.08.006

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title = "Recruitment and retention strategies in a clinical trial for children with chronic hepatitis c infection",

abstract = "Successful strategies for recruitment and retention (R & R) in pediatric trials are needed. The purpose of our study was to analyze the effectiveness of R&R in a trial for children with hepatitis C. Recruitment strategies were (1) Initial (months 0-12) and (2) extra effort (months 13-18). Initial strategies enrolled 70/114 (61%) of patients. Extra effort strategies included: (1) radio broadcasts, (2) contact with adult hepatologists, (3) dissemination of study material and (4) modification of the exclusion criteria. The overall retention rate was 84% at 2. years. Lessons learned will be valuable in designing future pediatric trials.",

keywords = "Hepatitis C virus, Pediatric clinical trials, Recruitment, Retention",

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note = "Funding Information: Extramural funding and commercial financial support: PEDS-C was funded in part by the National Institute of Diabetes and Digestive and Kidney Diseases in collaboration with the Food and Drug Administration Office of Orphan Products Development and under a contract between Johns Hopkins and Roche Laboratories, Inc. (Nutley, NJ). Roche supplied drugs and the costs of the data coordinating center and the central laboratory.",

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language = "English",

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AU - Garrett, Beth

AU - Hodik, Marcia

AU - Klipsch, Ann

AU - Young, Melissa

AU - Barton, Bruce

AU - Schwarz, Kathleen B.

N1 - Funding Information: Extramural funding and commercial financial support: PEDS-C was funded in part by the National Institute of Diabetes and Digestive and Kidney Diseases in collaboration with the Food and Drug Administration Office of Orphan Products Development and under a contract between Johns Hopkins and Roche Laboratories, Inc. (Nutley, NJ). Roche supplied drugs and the costs of the data coordinating center and the central laboratory.

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AB - Successful strategies for recruitment and retention (R & R) in pediatric trials are needed. The purpose of our study was to analyze the effectiveness of R&R in a trial for children with hepatitis C. Recruitment strategies were (1) Initial (months 0-12) and (2) extra effort (months 13-18). Initial strategies enrolled 70/114 (61%) of patients. Extra effort strategies included: (1) radio broadcasts, (2) contact with adult hepatologists, (3) dissemination of study material and (4) modification of the exclusion criteria. The overall retention rate was 84% at 2. years. Lessons learned will be valuable in designing future pediatric trials.

KW - Hepatitis C virus

KW - Pediatric clinical trials

KW - Recruitment

KW - Retention

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Recruitment and retention strategies in a clinical trial for children with chronic hepatitis c infection

Abstract

Keywords

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