Reconstructing a disease: What essential features of the retinoic acid receptor fusion oncoproteins generate acute promyelocytic leukemia?

Jonathan D. Licht

Research output: Contribution to journalShort surveypeer-review

70 Scopus citations

Abstract

Acute promyelocytic leukemia (APL) is associated with rearrangement of the retinoic acid receptor α (RARα) gene leading to the formation of chimeric receptor proteins. In this issue of Cancer Cell, studies by Kwok et al. and Sternsdorf et al. indicate that the ability of the RARα oncoproteins to dimerize/multimerize is an essential feature required for the development of disease. Homodimerization allows RARα to bind to corepressors with increased affinity and the ability to bind to novel DNA sequences. However, artificial RARα dimers were weak oncogenes in vivo, indicating that the fusion partners confer additional properties to RARα to efficiently generate disease.

Original languageEnglish
Pages (from-to)73-74
Number of pages2
JournalCancer Cell
Volume9
Issue number2
DOIs
StatePublished - Feb 2006

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