TY - JOUR
T1 - Reconciling variable findings of white matter integrity in major depressive disorder
AU - Choi, Ki Sueng
AU - Holtzheimer, Paul E.
AU - Franco, Alexandre R.
AU - Kelley, Mary E.
AU - Dunlop, Boadie W.
AU - Hu, Xiaoping P.
AU - Mayberg, Helen S.
N1 - Funding Information:
This research was supported by R01 MH073719 (HSM), CIDAR FP105 (HSM), K23 MH077869 (PEH), and a NARSAD Young Investigator Award (PEH). Dr Dunlop is supported by NIMH grant K23 MH086690. Dr Mayberg receives consulting fees from St. Jude Medical Neuromo-dulation and Eli Lilly and IP licensing fees from St. Jude Medical Neuromodulation. Dr Holtzheimer has received consulting fees from St. Jude Medical Neuromodulation and Cervel Neurotech and an honorarium from Johnson and Johnson. Dr Dunlop has received grant support from Novartis, Pfizer, BMS, Forest, and GSK, and has received consulting fees from Hoffman LaRoche, Pfizer, and BMS. The other authors declare no conflict of interest.
PY - 2014/5
Y1 - 2014/5
N2 - Diffusion tensor imaging (DTI) has been used to evaluate white matter (WM) integrity in major depressive disorder (MDD), with several studies reporting differences between depressed patients and controls. However, these findings are variable and taken from relatively small studies often using suboptimal analytic approaches. The presented DTI study examined WM integrity in large samples of medication-free MDD patients (n=134) and healthy controls (n=54) using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) approaches, and rigorous statistical thresholds. Compared with health control subjects, MDD patients show no significant differences in fractional anisotropy, radial diffusivity, mean diffusivity, and axonal diffusivity with either the VBM or the TBSS approach. Our findings suggest that disrupted WM integrity does not have a major role in the neurobiology of MDD in this relatively large study using optimal imaging acquisition and analysis; however, this does not eliminate the possibility that certain patient subgroups show WM disruption associated with depression.
AB - Diffusion tensor imaging (DTI) has been used to evaluate white matter (WM) integrity in major depressive disorder (MDD), with several studies reporting differences between depressed patients and controls. However, these findings are variable and taken from relatively small studies often using suboptimal analytic approaches. The presented DTI study examined WM integrity in large samples of medication-free MDD patients (n=134) and healthy controls (n=54) using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) approaches, and rigorous statistical thresholds. Compared with health control subjects, MDD patients show no significant differences in fractional anisotropy, radial diffusivity, mean diffusivity, and axonal diffusivity with either the VBM or the TBSS approach. Our findings suggest that disrupted WM integrity does not have a major role in the neurobiology of MDD in this relatively large study using optimal imaging acquisition and analysis; however, this does not eliminate the possibility that certain patient subgroups show WM disruption associated with depression.
KW - depression
KW - diffusion tensor imaging
KW - fractional anisotropy
KW - magnetic resonance imaging
KW - major depressive disorder
KW - white matter
UR - https://www.scopus.com/pages/publications/84900795944
U2 - 10.1038/npp.2013.345
DO - 10.1038/npp.2013.345
M3 - Article
C2 - 24352368
AN - SCOPUS:84900795944
SN - 0893-133X
VL - 39
SP - 1332
EP - 1339
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 6
ER -