Recombinant HDL-like nanoparticles: A specific contrast agent for MRI of atherosclerotic plaques

Juan C. Frias; Kevin Jon Williams; Edward A. Fisher; Zahi A. Fayad

doi:10.1021/ja044911a

Recombinant HDL-like nanoparticles: A specific contrast agent for MRI of atherosclerotic plaques

Juan C. Frias, Kevin Jon Williams, Edward A. Fisher, Zahi A. Fayad

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292 Scopus citations

Abstract

A new contrast agent for MRI based on recombinant HDL-like nanoparticles has been prepared. It shows a great potential as a contrast agent for atherosclerotic plaques in a relative short time (24 h post-injection) as it is selective for the plaques and is an endogenous molecule. It also can distinguish between different types of plaques as the enhancement obtained is different, depending on plaque composition.

Original language	English
Pages (from-to)	16316-16317
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	50
DOIs	https://doi.org/10.1021/ja044911a
State	Published - 22 Dec 2004

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abstract = "A new contrast agent for MRI based on recombinant HDL-like nanoparticles has been prepared. It shows a great potential as a contrast agent for atherosclerotic plaques in a relative short time (24 h post-injection) as it is selective for the plaques and is an endogenous molecule. It also can distinguish between different types of plaques as the enhancement obtained is different, depending on plaque composition.",

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Recombinant HDL-like nanoparticles: A specific contrast agent for MRI of atherosclerotic plaques

Abstract

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