Recognition of influenza A virus nucleoprotein by an H-2-restricted cytotoxic T-cell clone

A. R.M. Townsend; J. J. Skehel; P. M. Taylor; P. Palese

doi:10.1016/0042-6822(84)90413-6

Recognition of influenza A virus nucleoprotein by an H-2-restricted cytotoxic T-cell clone

A. R.M. Townsend, J. J. Skehel, P. M. Taylor, P. Palese

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Abstract

Cytotoxic T-cell clones raised against X-31 (H3N2) influenza virus in C57BL/6 mice can be directed against an influenza A virus subtype specific determinant (1). A representative T-cell clone (A3.1) has been used in combination with a set of genetically typed recombinant viruses, to show that the A/PR/8/34 nucleoprotein can be responsible for cytotoxic T-lymphocyte recognition of infected target cells.

Original language	English
Pages (from-to)	456-459
Number of pages	4
Journal	Virology
Volume	133
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(84)90413-6
State	Published - Mar 1984

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title = "Recognition of influenza A virus nucleoprotein by an H-2-restricted cytotoxic T-cell clone",

abstract = "Cytotoxic T-cell clones raised against X-31 (H3N2) influenza virus in C57BL/6 mice can be directed against an influenza A virus subtype specific determinant (1). A representative T-cell clone (A3.1) has been used in combination with a set of genetically typed recombinant viruses, to show that the A/PR/8/34 nucleoprotein can be responsible for cytotoxic T-lymphocyte recognition of infected target cells.",

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AU - Palese, P.

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AB - Cytotoxic T-cell clones raised against X-31 (H3N2) influenza virus in C57BL/6 mice can be directed against an influenza A virus subtype specific determinant (1). A representative T-cell clone (A3.1) has been used in combination with a set of genetically typed recombinant viruses, to show that the A/PR/8/34 nucleoprotein can be responsible for cytotoxic T-lymphocyte recognition of infected target cells.

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Recognition of influenza A virus nucleoprotein by an H-2-restricted cytotoxic T-cell clone

Abstract

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