Recent trends in food protein–induced enterocolitis syndrome (FPIES)

Mary Grace Baker, Hugh A. Sampson

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Food protein–induced enterocolitis syndrome (FPIES) was first described in detail in the late 20th century as a non–IgE-mediated food allergy characterized by delayed gastrointestinal symptoms after ingestion of a trigger food. Although the initial case series reported infants reacting to cow's milk– and soy-based formulas, we now recognize that FPIES affects patients across the age spectrum. This brief review highlights our evolving understanding of FPIES with a discussion of triggers, epidemiology, food challenges, and pathophysiology.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalJournal of Allergy and Clinical Immunology
Issue number1
StatePublished - Jan 2023


  • Food protein–induced enterocolitis syndrome
  • food allergy
  • food hypersensitivity
  • food intolerance


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