TY - JOUR
T1 - Recent progress in single-cell cancer genomics
AU - Tsoucas, Daphne
AU - Yuan, Guo Cheng
N1 - Publisher Copyright:
© 2017 The Author(s)
PY - 2017/2/1
Y1 - 2017/2/1
N2 - The advent of single-cell sequencing has been revolutionary to the field of cancer genomics. Perfectly suited to capture cancer's heterogeneous nature, single-cell analyses provide information bulk sequencing could never hope to uncover. Many mechanisms of cancer have yet to be fully understood, and single-cell approaches are showing promise in their abilities to uncover these mysteries. Here we focus on the most recent single-cell methods for cancer genomics, and how they are not only providing insights into the inner workings of cancer, but are also transforming individualized therapy and non-invasive monitoring and diagnosis.
AB - The advent of single-cell sequencing has been revolutionary to the field of cancer genomics. Perfectly suited to capture cancer's heterogeneous nature, single-cell analyses provide information bulk sequencing could never hope to uncover. Many mechanisms of cancer have yet to be fully understood, and single-cell approaches are showing promise in their abilities to uncover these mysteries. Here we focus on the most recent single-cell methods for cancer genomics, and how they are not only providing insights into the inner workings of cancer, but are also transforming individualized therapy and non-invasive monitoring and diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=85010223944&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2017.01.002
DO - 10.1016/j.gde.2017.01.002
M3 - Review article
C2 - 28126650
AN - SCOPUS:85010223944
SN - 0959-437X
VL - 42
SP - 22
EP - 32
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -