@article{a22c50b3ee6740ae967f28830c9fde44,
title = "Recent Progress in Lyme Disease and Remaining Challenges",
abstract = "Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has been controversial, mounting evidence supports the idea that a substantial number of patients experience persistent symptoms following treatment. The research community has largely lacked the necessary funding to properly advance the scientific and clinical understanding of the disease, or to develop and evaluate innovative approaches for prevention, diagnosis, and treatment. Given the many outstanding questions raised into the diagnosis, clinical presentation and treatment of Lyme disease, and the underlying molecular mechanisms that trigger persistent disease, there is an urgent need for more support. This review article summarizes progress over the past 5 years in our understanding of Lyme and tick-borne diseases in the United States and highlights remaining challenges.",
keywords = "Lyme disease, PTLD, diagnosis, field building, pathogenesis, prevention, treatment, vaccine",
author = "Bobe, {Jason R.} and Jutras, {Brandon L.} and Horn, {Elizabeth J.} and Embers, {Monica E.} and Allison Bailey and Moritz, {Robert L.} and Ying Zhang and Soloski, {Mark J.} and Ostfeld, {Richard S.} and Marconi, {Richard T.} and John Aucott and Avi Ma'ayan and Felicia Keesing and Kim Lewis and {Ben Mamoun}, Choukri and Rebman, {Alison W.} and McClune, {Mecaila E.} and Breitschwerdt, {Edward B.} and Reddy, {Panga Jaipal} and Ricardo Maggi and Frank Yang and Bennett Nemser and Aydogan Ozcan and Omai Garner and {Di Carlo}, Dino and Zachary Ballard and Joung, {Hyou Arm} and Albert Garcia-Romeu and Griffiths, {Roland R.} and Nicole Baumgarth and Fallon, {Brian A.}",
note = "Funding Information: All authors are supported by funding from the Steven & Alexandra Cohen Foundation. Additional funding is provided by grants from the Global Lyme Alliance and NIH/NIAID R01AI157007 (NB); Bay Area Lyme Foundation (JRB); NIH R01 AI083640 (FY); NIAID/NIH R21AI133335 and R21AI142302 (RLM and PJR). Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Bobe, Jutras, Horn, Embers, Bailey, Moritz, Zhang, Soloski, Ostfeld, Marconi, Aucott, Ma'ayan, Keesing, Lewis, Ben Mamoun, Rebman, McClune, Breitschwerdt, Reddy, Maggi, Yang, Nemser, Ozcan, Garner, Di Carlo, Ballard, Joung, Garcia-Romeu, Griffiths, Baumgarth and Fallon.",
year = "2021",
month = aug,
day = "18",
doi = "10.3389/fmed.2021.666554",
language = "English",
volume = "8",
journal = "Frontiers in Medicine",
issn = "2296-858X",
publisher = "Frontiers Media S.A.",
}