Recent Developments in Magnetic Hyperthermia Therapy (MHT) and Magnetic Particle Imaging (MPI) in the Brain Tumor Field: A Scoping Review and Meta-Analysis

Frederika Rentzeperis, Daniel Rivera, Jack Y. Zhang, Cole Brown, Tirone Young, Benjamin Rodriguez, Alexander Schupper, Gabrielle Price, Jack Gomberg, Tyree Williams, Alexandros Bouras, Constantinos Hadjipanayis

Research output: Contribution to journalReview articlepeer-review

Abstract

Magnetic hyperthermia therapy (MHT) is a promising treatment modality for brain tumors using magnetic nanoparticles (MNPs) locally delivered to the tumor and activated with an external alternating magnetic field (AMF) to generate antitumor effects through localized heating. Magnetic particle imaging (MPI) is an emerging technology offering strong signal-to-noise for nanoparticle localization. A scoping review was performed by systematically querying Pubmed, Scopus, and Embase. In total, 251 articles were returned, 12 included. Articles were analyzed for nanoparticle type used, MHT parameters, and MPI applications. Preliminary results show that MHT is an exciting treatment modality with unique advantages over current heat-based therapies for brain cancer. Effective application relies on the further development of unique magnetic nanoparticle constructs and imaging modalities, such as MPI, that can enable real-time MNP imaging for improved therapeutic outcomes.

Original languageEnglish
Article number559
JournalMicromachines
Volume15
Issue number5
DOIs
StatePublished - May 2024

Keywords

  • astrocytoma
  • glioblastoma
  • glioma
  • hyperthermia
  • magnetic hyperthermia therapy
  • magnetic particle imaging
  • nanoparticles

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