Recent advances in the use of microfluidic technologies for single cell analysis

Travis W. Murphy, Qiang Zhang, Lynette B. Naler, Sai Ma, Chang Lu

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations

Abstract

The inherent heterogeneity in cell populations has become of great interest and importance as analytical techniques have improved over the past decades. With the advent of personalized medicine, understanding the impact of this heterogeneity has become an important challenge for the research community. Many different microfluidic approaches with varying levels of throughput and resolution exist to study single cell activity. In this review, we take a broad view of the recent microfluidic developments in single cell analysis based on microwell, microchamber, and droplet platforms. We cover physical, chemical, and molecular biology approaches for cellular and molecular analysis including newly emerging genome-wide analysis.

Original languageEnglish
Pages (from-to)60-80
Number of pages21
JournalThe Analyst
Volume143
Issue number1
DOIs
StatePublished - 7 Jan 2018
Externally publishedYes

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