Recent Advances in the Use of Chimeric Antigen Receptor–Expressing T-Cell Therapies for Treatment of Multiple Myeloma: Clinically advanced CAR-T therapies for RRMM

Thomas Martin, Carolyn C. Jackson, Lida Pacaud, Deepu Madduri, Sundar Jagannath

Research output: Contribution to journalShort surveypeer-review

5 Scopus citations

Abstract

Introduction: Chimeric antigen receptor T cell (CAR-T) therapies have revolutionized the treatment paradigm for heavily pretreated B-cell malignancies such as large B-cell lymphoma. There is a major unmet need for effective treatments for heavily pretreated relapsed/refractory multiple myeloma (RRMM), for which many CAR-T therapies are under active clinical investigation. Goal of the review: This review provides an overview of recently updated clinical trial data and indirect treatment comparison analyses regarding two clinically advanced CAR-T therapies, idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel). Discussion: Recently presented data after prolonged follow-up periods for ide-cel (KarMMa) and cilta-cel (CARTITUDE-1) have demonstrated that both therapies have the potential to elicit responses in individuals with heavily pretreated RRMM. Indirect treatment comparisons between cilta-cel and ide-cel suggest cilta-cel is associated with deeper and more durable responses than ide-cel in triple class-exposed RRMM; however, these types of comparisons have limitations and direct head-to-head trials are needed to confirm these findings. Additional indirect treatment comparisons conducted separately for ide-cel and cilta-cel have demonstrated that these CAR-T therapies hold promise for substantial clinical benefit relative to currently available treatments for RRMM. Further considerations, including safety profiles and real-world treatment considerations, are also discussed. Conclusion: Data collected to date support CAR-T therapies holding substantial promise for patients with heavily pretreated RRMM relative to other currently available therapies. Additional real-world data will help provide further insights into the comparative efficacy and safety profiles of these treatments in RRMM as these treatments become more widely available.

Original languageEnglish
Pages (from-to)22-27
Number of pages6
JournalClinical Lymphoma, Myeloma and Leukemia
Volume23
Issue number1
DOIs
StatePublished - Jan 2023

Keywords

  • CAR-T
  • RRMM
  • cilta-cel
  • ide-cel
  • multiple myeloma
  • relapsed refractory multiple myeloma

Fingerprint

Dive into the research topics of 'Recent Advances in the Use of Chimeric Antigen Receptor–Expressing T-Cell Therapies for Treatment of Multiple Myeloma: Clinically advanced CAR-T therapies for RRMM'. Together they form a unique fingerprint.

Cite this