Recent advances in the diagnosis of drug-induced liver injury

Taqwa Ahmed, Jawad Ahmad

Research output: Contribution to journalReview articlepeer-review

Abstract

Drug-induced liver injury (DILI) is a major problem in the United States, commonly leading to hospital admission. Diagnosing DILI is difficult as it is a diagnosis of exclusion requiring a temporal relationship between drug exposure and liver injury and a thorough work up for other causes. In addition, DILI has a very variable clinical and histologic presentation that can mimic many different etiologies of liver disease. Objective scoring systems can assess the probability that a drug caused the liver injury but liver biopsy findings are not part of the criteria used in these systems. This review will address some of the recent updates to the scoring systems and the role of liver biopsy in the diagnosis of DILI.

Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalWorld Journal of Hepatology
Volume16
Issue number2
DOIs
StatePublished - 2024

Keywords

  • Diagnosis
  • Drug induced liver injury
  • Liver biopsy
  • RECAM
  • RUCAM

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