Reappraisal of the liver benzpyrene hydroxylase synthesized de novo after treatment of rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene

I. B. Tsyrlov; O. B. Chasovnikova; A. Yu Grishanova; V. V. Lyakhovich

doi:10.1016/0014-5793(86)80410-0

Reappraisal of the liver benzpyrene hydroxylase synthesized de novo after treatment of rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene

I. B. Tsyrlov
, O. B. Chasovnikova
, A. Yu Grishanova
, V. V. Lyakhovich

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The dynamics of the inductive effects of MC and TCDD upon rat liver microsomal benzpyrene hydroxylase and the main properties of the de novo synthesized hemoproteins have been compared. The inadequacy of expression of the enzyme activity per total cytochrome P-448 content has been established. It was concluded that TCDD microsomes have a relatively low content of benzpyrene hydroxylase with a higher molecular activity than the enzyme from MC microsomes.

Original language	English
Pages (from-to)	225-228
Number of pages	4
Journal	FEBS Letters
Volume	198
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(86)80410-0
State	Published - 31 Mar 1986
Externally published	Yes

Keywords

Antibody
Benzpyrene hydroxylase
Cytochrome P-448
Enzyme activity
Hemoprotein synthesis

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10.1016/0014-5793(86)80410-0

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title = "Reappraisal of the liver benzpyrene hydroxylase synthesized de novo after treatment of rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene",

abstract = "The dynamics of the inductive effects of MC and TCDD upon rat liver microsomal benzpyrene hydroxylase and the main properties of the de novo synthesized hemoproteins have been compared. The inadequacy of expression of the enzyme activity per total cytochrome P-448 content has been established. It was concluded that TCDD microsomes have a relatively low content of benzpyrene hydroxylase with a higher molecular activity than the enzyme from MC microsomes.",

keywords = "Antibody, Benzpyrene hydroxylase, Cytochrome P-448, Enzyme activity, Hemoprotein synthesis",

author = "Tsyrlov, \{I. B.\} and Chasovnikova, \{O. B.\} and Grishanova, \{A. Yu\} and Lyakhovich, \{V. V.\}",

year = "1986",

month = mar,

day = "31",

doi = "10.1016/0014-5793(86)80410-0",

language = "English",

volume = "198",

pages = "225--228",

journal = "FEBS Letters",

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publisher = "John Wiley and Sons Inc.",

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T1 - Reappraisal of the liver benzpyrene hydroxylase synthesized de novo after treatment of rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene

AU - Tsyrlov, I. B.

AU - Chasovnikova, O. B.

AU - Grishanova, A. Yu

AU - Lyakhovich, V. V.

PY - 1986/3/31

Y1 - 1986/3/31

N2 - The dynamics of the inductive effects of MC and TCDD upon rat liver microsomal benzpyrene hydroxylase and the main properties of the de novo synthesized hemoproteins have been compared. The inadequacy of expression of the enzyme activity per total cytochrome P-448 content has been established. It was concluded that TCDD microsomes have a relatively low content of benzpyrene hydroxylase with a higher molecular activity than the enzyme from MC microsomes.

AB - The dynamics of the inductive effects of MC and TCDD upon rat liver microsomal benzpyrene hydroxylase and the main properties of the de novo synthesized hemoproteins have been compared. The inadequacy of expression of the enzyme activity per total cytochrome P-448 content has been established. It was concluded that TCDD microsomes have a relatively low content of benzpyrene hydroxylase with a higher molecular activity than the enzyme from MC microsomes.

KW - Antibody

KW - Benzpyrene hydroxylase

KW - Cytochrome P-448

KW - Enzyme activity

KW - Hemoprotein synthesis

UR - https://www.scopus.com/pages/publications/0022493629

U2 - 10.1016/0014-5793(86)80410-0

DO - 10.1016/0014-5793(86)80410-0

M3 - Article

C2 - 3956732

AN - SCOPUS:0022493629

SN - 0014-5793

VL - 198

SP - 225

EP - 228

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Reappraisal of the liver benzpyrene hydroxylase synthesized de novo after treatment of rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene

Abstract

Keywords

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