Readmission for cardiac and non-cardiac causes among adults with epilepsy or multiple sclerosis – A nationwide analysis

Hernan Nicolas Lemus, Nathalie Jetté, Churl Su Kwon, Anusha K. Yeshokumar, Mandip S. Dhamoon, Madhu Mazumdar, Parul Agarwal

Research output: Contribution to journalArticlepeer-review


Purpose: The aim of this study was to determine proportions of 30-day cardiac readmissions in adults with epilepsy compared to multiple sclerosis (MS) or those with neither condition. Predictors and causes of readmissions were also examined. Methods: We used the 2014 Nationwide Readmissions Database and ICD-9-CM codes to identify people with epilepsy, MS, and without epilepsy or MS. Multinomial logistic regressions were fitted to: (1) examine association between 30-day readmissions and epilepsy, MS or neither, and (2) to describe causes and predictors of 30-day readmission for cardiac readmissions in epilepsy. Results: Out of 6,870,508 adults admitted in 2014, 202,938 (2.98%) had epilepsy and 29,556 (0.45%) had MS. The proportion of 30-day readmission for epilepsy and MS were, respectively: (1) due to cardiac causes (0.17% vs. 0.13%); (2) due to other causes (13.89% vs. 10.61%). The odds of 30-day cardiac readmission in those with epilepsy and MS were lower compared to those without either condition (OR = 0.64, 95% CI 0.57–0.73, p < 0.0001; OR = 0.60, 95% CI 0.43–0.84, p = 0.003). Among those with epilepsy, increasing age (OR = 1.03, 95% CI 1.02–1.04, p < 0.0001) and a Charlson comorbidity index ≥1 (OR = 1.79, 95% CI 1.24–2.60, p = 0.002) were associated with higher odds of 30-day cardiac readmission. A higher proportion of those with epilepsy readmitted within 30-days due to cardiac causes died in hospital (10.09%) compared to those with MS (not reportable due to cell frequency <10) or without epilepsy or MS (5.61%). Conclusion: Those admitted to a hospital and living with epilepsy had a higher proportion of cardiac readmissions and death in hospital when compared to those living with MS, and the determinants are likely multifactorial. These findings are important and need to be further explored to identify strategies to prevent readmissions due to any cause and treatments that could reduce mortality.

Original languageEnglish
Article number108338
JournalEpilepsy and Behavior
StatePublished - Nov 2021


  • Cardiovascular
  • Demyelinating disease
  • Epidemiology
  • Hospitalization
  • Mortality
  • Seizure


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