Reactive keratoma of the central corneal epithelium

Paul T. Finger, Kimberly J. Chin, Jeffrey J. Wong, Codrin E. Iacob

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


PURPOSE. The authors present a unique corneal tumor. METHODS. A 75-year-old gardener presented with a 1-year history of a slowly growing central corneal lesion with progressive visual loss. We performed an ophthalmic examination, slit lamp photography, high-frequency ultrasonography, and culture with sensitivity (followed by therapeutic scrape biopsy). RESULTS. Clinical examination revealed a gray-white central corneal tumor without extension to the limbus. No significant tumor neovascularization or intraocular inflammation was noted. High frequency ultrasound revealed no penetration of the corneal stroma. The tumor was removed with a platinum spatula. Histopathology revealed simple hyperkeratosis characterized by stratified hyperkeratotic corneal epithelium with metaplastic granular layer characteristic of epidermis. Few and focal clusters of passenger bacteria were found (as seen in cutaneous leukoplakia). Cultures revealed a few Gram-positive cocci and no fungus. A human papilloma virus wide-screen spectrum assay (in situ hybridization) was negative. CONCLUSIONS. The authors present a benign keratoma of the central corneal epithelium. High frequency ultrasound and scrape biopsy histopathologic techniques were used to diagnose and treat this keratoleukoma caused by a reactive keratoma as well as improve his vision.

Original languageEnglish
Pages (from-to)484-486
Number of pages3
JournalEuropean Journal of Ophthalmology
Issue number3
StatePublished - 2009
Externally publishedYes


  • Benign keratoma
  • Central corneal epithelium
  • Keratoleukoma
  • Reactive keratoma


Dive into the research topics of 'Reactive keratoma of the central corneal epithelium'. Together they form a unique fingerprint.

Cite this