Reactions to transfusions

Patrick Maffucci; Lyle Nolasco; Marc Sherwin; Natalie Smith

doi:10.1017/9781009334792.040

Reactions to transfusions

Patrick Maffucci
, Lyle Nolasco
, Marc Sherwin
, Natalie Smith

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Transfusion of blood products can lead to a number of complications. In this chapter, the presentation, diagnosis, mechanism of action, incidence, treatment, and prevention of transfusion reactions are outlined. The reactions summarized in comparison with one another are febrile non-hemolytic, allergic, and hemolytic transfusion reactions. Other complications of transfusions, such as infections, immunosuppression, citrate intoxication, and acid-base and electrolyte abnormalities, are also explained, along with those associated with massive transfusions, such as coagulopathies and hypothermia. Pulmonary complications of transfusions, namely Transfusion-Related Acute Lung Injury (TRALI) and Transfusion-Associated Circulatory Overload (TACO), have been reviewed with the most up-to-date literature. The presentation, diagnosis, mechanism of action, incidence, treatment, and prevention of these two reactions are outlined, as well.

Original language	English
Title of host publication	BASIC Essentials
Subtitle of host publication	A Comprehensive Review for the Anesthesiology BASIC Exam
Publisher	Cambridge University Press
Pages	215-221
Number of pages	7
ISBN (Electronic)	9781009334792
ISBN (Print)	9781009334808
DOIs	https://doi.org/10.1017/9781009334792.040
State	Published - 13 Mar 2025

Keywords

ABO-incompatibility
AHTR
ATR
Acute hemolytic transfusion reaction
Allergic transfusion reaction
Alloantibodies
Blood storage
Citrate intoxication
Complications of massive transfusion
Complications of transfusions
DAT
DHTR
Delayed hemolytic transfusion reaction
Direct antiglobulin test
Donor antibodies
Donor leukocytes
FNHTR
Febrile non-hemolytic transfusion reaction
Hemolysis
Hypersensitivity reaction
Leukoreduction
Massive transfusion
Minor RBC antigen
Recipient antibodies
TACO
TRALI
Transfusion
Transfusion associated mortality
Transfusion immunosuppression
Transfusion infection
Transfusion-associated circulatory overload
Transfusion-related acute lung injury

Access to Document

10.1017/9781009334792.040

Cite this

@inbook{403c316b408c401cad6ec81405fe7b42,

title = "Reactions to transfusions",

abstract = "Transfusion of blood products can lead to a number of complications. In this chapter, the presentation, diagnosis, mechanism of action, incidence, treatment, and prevention of transfusion reactions are outlined. The reactions summarized in comparison with one another are febrile non-hemolytic, allergic, and hemolytic transfusion reactions. Other complications of transfusions, such as infections, immunosuppression, citrate intoxication, and acid-base and electrolyte abnormalities, are also explained, along with those associated with massive transfusions, such as coagulopathies and hypothermia. Pulmonary complications of transfusions, namely Transfusion-Related Acute Lung Injury (TRALI) and Transfusion-Associated Circulatory Overload (TACO), have been reviewed with the most up-to-date literature. The presentation, diagnosis, mechanism of action, incidence, treatment, and prevention of these two reactions are outlined, as well.",

keywords = "ABO-incompatibility, AHTR, ATR, Acute hemolytic transfusion reaction, Allergic transfusion reaction, Alloantibodies, Blood storage, Citrate intoxication, Complications of massive transfusion, Complications of transfusions, DAT, DHTR, Delayed hemolytic transfusion reaction, Direct antiglobulin test, Donor antibodies, Donor leukocytes, FNHTR, Febrile non-hemolytic transfusion reaction, Hemolysis, Hypersensitivity reaction, Leukoreduction, Massive transfusion, Minor RBC antigen, Recipient antibodies, TACO, TRALI, Transfusion, Transfusion associated mortality, Transfusion immunosuppression, Transfusion infection, Transfusion-associated circulatory overload, Transfusion-related acute lung injury",

author = "Patrick Maffucci and Lyle Nolasco and Marc Sherwin and Natalie Smith",

year = "2025",

month = mar,

day = "13",

doi = "10.1017/9781009334792.040",

language = "English",

isbn = "9781009334808",

pages = "215--221",

booktitle = "BASIC Essentials",

publisher = "Cambridge University Press",

address = "United Kingdom",

}

TY - CHAP

T1 - Reactions to transfusions

AU - Maffucci, Patrick

AU - Nolasco, Lyle

AU - Sherwin, Marc

AU - Smith, Natalie

PY - 2025/3/13

Y1 - 2025/3/13

N2 - Transfusion of blood products can lead to a number of complications. In this chapter, the presentation, diagnosis, mechanism of action, incidence, treatment, and prevention of transfusion reactions are outlined. The reactions summarized in comparison with one another are febrile non-hemolytic, allergic, and hemolytic transfusion reactions. Other complications of transfusions, such as infections, immunosuppression, citrate intoxication, and acid-base and electrolyte abnormalities, are also explained, along with those associated with massive transfusions, such as coagulopathies and hypothermia. Pulmonary complications of transfusions, namely Transfusion-Related Acute Lung Injury (TRALI) and Transfusion-Associated Circulatory Overload (TACO), have been reviewed with the most up-to-date literature. The presentation, diagnosis, mechanism of action, incidence, treatment, and prevention of these two reactions are outlined, as well.

AB - Transfusion of blood products can lead to a number of complications. In this chapter, the presentation, diagnosis, mechanism of action, incidence, treatment, and prevention of transfusion reactions are outlined. The reactions summarized in comparison with one another are febrile non-hemolytic, allergic, and hemolytic transfusion reactions. Other complications of transfusions, such as infections, immunosuppression, citrate intoxication, and acid-base and electrolyte abnormalities, are also explained, along with those associated with massive transfusions, such as coagulopathies and hypothermia. Pulmonary complications of transfusions, namely Transfusion-Related Acute Lung Injury (TRALI) and Transfusion-Associated Circulatory Overload (TACO), have been reviewed with the most up-to-date literature. The presentation, diagnosis, mechanism of action, incidence, treatment, and prevention of these two reactions are outlined, as well.

KW - ABO-incompatibility

KW - AHTR

KW - ATR

KW - Acute hemolytic transfusion reaction

KW - Allergic transfusion reaction

KW - Alloantibodies

KW - Blood storage

KW - Citrate intoxication

KW - Complications of massive transfusion

KW - Complications of transfusions

KW - DAT

KW - DHTR

KW - Delayed hemolytic transfusion reaction

KW - Direct antiglobulin test

KW - Donor antibodies

KW - Donor leukocytes

KW - FNHTR

KW - Febrile non-hemolytic transfusion reaction

KW - Hemolysis

KW - Hypersensitivity reaction

KW - Leukoreduction

KW - Massive transfusion

KW - Minor RBC antigen

KW - Recipient antibodies

KW - TACO

KW - TRALI

KW - Transfusion

KW - Transfusion associated mortality

KW - Transfusion immunosuppression

KW - Transfusion infection

KW - Transfusion-associated circulatory overload

KW - Transfusion-related acute lung injury

UR - https://www.scopus.com/pages/publications/105010553350

U2 - 10.1017/9781009334792.040

DO - 10.1017/9781009334792.040

M3 - Chapter

AN - SCOPUS:105010553350

SN - 9781009334808

SP - 215

EP - 221

BT - BASIC Essentials

PB - Cambridge University Press

ER -

Reactions to transfusions

Abstract

Keywords

Access to Document

Fingerprint

Cite this