TY - JOUR
T1 - Reaction of carbohydrates with Vilsmeier reagent
T2 - A tandem selective chloro O-formylation of sugars
AU - Thota, Niranjan
AU - Mukherjee, Debaraj
AU - Reddy, Mallepally Venkat
AU - Yousuf, Syed Khalid
AU - Koul, Surrinder
AU - Taneja, Subhash Chandra
PY - 2009
Y1 - 2009
N2 - A convenient and efficient method for selective replacement of the primary hydroxyl groups of sugars by chlorine with concomitant O-formylation, compatible with the presence of a variety of functional groups, has been developed using the Vilsmeier-Haack reaction. Sugars having free primary hydroxyl groups mostly afforded the chloro-O-formylated product while sugars devoid of primary hydroxyl groups yielded only O-formylated products.
AB - A convenient and efficient method for selective replacement of the primary hydroxyl groups of sugars by chlorine with concomitant O-formylation, compatible with the presence of a variety of functional groups, has been developed using the Vilsmeier-Haack reaction. Sugars having free primary hydroxyl groups mostly afforded the chloro-O-formylated product while sugars devoid of primary hydroxyl groups yielded only O-formylated products.
UR - http://www.scopus.com/inward/record.url?scp=67649319488&partnerID=8YFLogxK
U2 - 10.1039/b900026g
DO - 10.1039/b900026g
M3 - Article
C2 - 19300809
AN - SCOPUS:67649319488
SN - 1477-0520
VL - 7
SP - 1280
EP - 1283
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 7
ER -