@article{a74b266106094a79a9e376e2cc723e07,
title = "Rationale and design of the Kidney Precision Medicine Project",
abstract = "Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.",
keywords = "acute kidney injury, chronic kidney disease, diabetes, hypertension, precision medicine",
author = "{Kidney Precision Medicine Project} and {de Boer}, {Ian H.} and Alpers, {Charles E.} and Azeloglu, {Evren U.} and Balis, {Ulysses G.J.} and Barasch, {Jonathan M.} and Laura Barisoni and Blank, {Kristina N.} and Bomback, {Andrew S.} and Keith Brown and Dagher, {Pierre C.} and Dighe, {Ashveena L.} and Eadon, {Michael T.} and El-Achkar, {Tarek M.} and Gaut, {Joseph P.} and Nir Hacohen and Yongqun He and Hodgin, {Jeffrey B.} and Sanjay Jain and Kellum, {John A.} and Krzysztof Kiryluk and Richard Knight and Laszik, {Zoltan G.} and Chrysta Lienczewski and Mariani, {Laura H.} and McClelland, {Robyn L.} and Steven Menez and Moledina, {Dennis G.} and Mooney, {Sean D.} and O'Toole, {John F.} and Palevsky, {Paul M.} and Parikh, {Chirag R.} and Poggio, {Emilio D.} and Rosas, {Sylvia E.} and Rosengart, {Matthew R.} and Sarwal, {Minnie M.} and Schaub, {Jennifer A.} and Sedor, {John R.} and Kumar Sharma and Becky Steck and Toto, {Robert D.} and Troyanskaya, {Olga G.} and Tuttle, {Katherine R.} and Vazquez, {Miguel A.} and Waikar, {Sushrut S.} and Kayleen Williams and Wilson, {Francis Perry} and Kun Zhang and Ravi Iyengar and Evren Azeloglu and Jens Hansen",
note = "Funding Information: The KPMP is funded by the following grants from the NIDDK: U2C DK114886, UH3DK114861, UH3DK114866, UH3DK114870, UH3DK114908, UH3DK114915, UH3DK114926, UH3DK114907, UH3DK114920, UH3DK114923, UH3DK114933, and UH3DK114937. The KPMP investigators thank the members of the Division of Kidney, Urologic, and Hematologic Diseases of the NIDDK who initiated and guided development of the KPMP, the KPMP External Expert Panel, the KPMP Data Safety Monitoring Board, and the Washington University Institutional Review Board. Funding Information: The KPMP is funded by the following grants from the NIDDK: U2C DK114886, UH3DK114861, UH3DK114866, UH3DK114870, UH3DK114908, UH3DK114915, UH3DK114926, UH3DK114907, UH3DK114920, UH3DK114923, UH3DK114933, and UH3DK114937. The KPMP investigators thank the members of the Division of Kidney, Urologic, and Hematologic Diseases of the NIDDK who initiated and guided development of the KPMP, the KPMP External Expert Panel, the KPMP Data Safety Monitoring Board, and the Washington University Institutional Review Board. Publisher Copyright: {\textcopyright} 2021 International Society of Nephrology",
year = "2021",
month = mar,
doi = "10.1016/j.kint.2020.08.039",
language = "English",
volume = "99",
pages = "498--510",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Elsevier Inc.",
number = "3",
}