@inbook{478bc69253f3489ea3042c19f97b6668,
title = "Rat model of cardiotoxic drug-induced cardiomyopathy",
abstract = "Cardiotoxicity from cancer drugs remains a clinical problem. To find reliable markers of cardiotoxicity, animal models were proposed and potential new diagnostic, markers have been actively investigated using these models. Here we describe our protocols, using male Sprague-Dawley rats, for inducing cardiomyopathy by single injection of high-dose doxorubicin (5–10, mg/kg) or multiple injections (2–4 times) of low-dose doxorubicin (2.5, mg/kg) with combined single injection of trastuzumab (10, mg/kg). The cardiotoxicity is evaluated by imaging modalities (echocardiography and nuclear imaging), serum troponin levels, and histopathological analyses.",
keywords = "Cardiotoxicity, Doxorubicin, Echocardiography, Left ventricular ejection fraction, Traszmab, Troponin",
author = "Takehiro Nakahara and Takashi Tanimoto and Petrov, \{Artiom D.\} and Kiyotake Ishikawa and Strauss, \{H. William\} and Jagat Narula",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2018.",
year = "2018",
doi = "10.1007/978-1-4939-8597-5\_17",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "221--232",
booktitle = "Methods in Molecular Biology",
}