Rat c-raf oncogene is located on chromosome 4 and may be activated by sequences from chromosome 13

Sigurdur Ingvarsson; Charlotte Asker; Josiane Szpirer; Göran Levan; George Klein

doi:10.1007/BF01534648

Rat c-raf oncogene is located on chromosome 4 and may be activated by sequences from chromosome 13

Sigurdur Ingvarsson
, Charlotte Asker
, Josiane Szpirer
, Göran Levan
, George Klein

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Activated forms of the protooncogene c-raf have been found to transform established lines of rodent fibroblasts after transfection with DNA from several human and rat tumors. Using Southern blot analysis of DNAs from rat × mouse somatic cell hybrids, we have mapped c-raf to rat chromosome 4. An exogenous sequence that was found juxtaposed to c-raf within transforming DNA originally derived from a rat hepatocellular carcinoma was localized to chromosome 13.

Original language	English
Pages (from-to)	401-405
Number of pages	5
Journal	Somatic Cell and Molecular Genetics
Volume	14
Issue number	4
DOIs	https://doi.org/10.1007/BF01534648
State	Published - Jul 1988
Externally published	Yes

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title = "Rat c-raf oncogene is located on chromosome 4 and may be activated by sequences from chromosome 13",

abstract = "Activated forms of the protooncogene c-raf have been found to transform established lines of rodent fibroblasts after transfection with DNA from several human and rat tumors. Using Southern blot analysis of DNAs from rat × mouse somatic cell hybrids, we have mapped c-raf to rat chromosome 4. An exogenous sequence that was found juxtaposed to c-raf within transforming DNA originally derived from a rat hepatocellular carcinoma was localized to chromosome 13.",

author = "Sigurdur Ingvarsson and Charlotte Asker and Josiane Szpirer and G{\"o}ran Levan and George Klein",

year = "1988",

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doi = "10.1007/BF01534648",

language = "English",

volume = "14",

pages = "401--405",

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T1 - Rat c-raf oncogene is located on chromosome 4 and may be activated by sequences from chromosome 13

AU - Ingvarsson, Sigurdur

AU - Asker, Charlotte

AU - Szpirer, Josiane

AU - Levan, Göran

AU - Klein, George

PY - 1988/7

Y1 - 1988/7

N2 - Activated forms of the protooncogene c-raf have been found to transform established lines of rodent fibroblasts after transfection with DNA from several human and rat tumors. Using Southern blot analysis of DNAs from rat × mouse somatic cell hybrids, we have mapped c-raf to rat chromosome 4. An exogenous sequence that was found juxtaposed to c-raf within transforming DNA originally derived from a rat hepatocellular carcinoma was localized to chromosome 13.

AB - Activated forms of the protooncogene c-raf have been found to transform established lines of rodent fibroblasts after transfection with DNA from several human and rat tumors. Using Southern blot analysis of DNAs from rat × mouse somatic cell hybrids, we have mapped c-raf to rat chromosome 4. An exogenous sequence that was found juxtaposed to c-raf within transforming DNA originally derived from a rat hepatocellular carcinoma was localized to chromosome 13.

UR - https://www.scopus.com/pages/publications/0023801163

U2 - 10.1007/BF01534648

DO - 10.1007/BF01534648

M3 - Article

C2 - 3399964

AN - SCOPUS:0023801163

SN - 0740-7750

VL - 14

SP - 401

EP - 405

JO - Somatic Cell and Molecular Genetics

JF - Somatic Cell and Molecular Genetics

IS - 4

ER -

Rat c-raf oncogene is located on chromosome 4 and may be activated by sequences from chromosome 13

Abstract

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