RASopathy mutations open new insights into the mechanism of BRAF activation

Arvin C. Dar; Donita C. Brady

doi:10.1016/j.molcel.2022.10.034

RASopathy mutations open new insights into the mechanism of BRAF activation

Arvin C. Dar
, Donita C. Brady

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Spencer-Smith et al. (2022)¹ investigate multiple functions of the BRAF cysteine-rich domain (CRD), finding distinct classes of RASopathy-associated BRAF mutations and unique features among RAF paralogs that may contribute to the spectrum of mutations observed in disease.

Original language	English
Pages (from-to)	4192-4193
Number of pages	2
Journal	Molecular Cell
Volume	82
Issue number	22
DOIs	https://doi.org/10.1016/j.molcel.2022.10.034
State	Published - 17 Nov 2022

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@article{0b6445bf93584a5f99abe860173cab8d,

title = "RASopathy mutations open new insights into the mechanism of BRAF activation",

abstract = "Spencer-Smith et al. (2022)1 investigate multiple functions of the BRAF cysteine-rich domain (CRD), finding distinct classes of RASopathy-associated BRAF mutations and unique features among RAF paralogs that may contribute to the spectrum of mutations observed in disease.",

author = "Dar, \{Arvin C.\} and Brady, \{Donita C.\}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = nov,

day = "17",

doi = "10.1016/j.molcel.2022.10.034",

language = "English",

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T1 - RASopathy mutations open new insights into the mechanism of BRAF activation

AU - Dar, Arvin C.

AU - Brady, Donita C.

PY - 2022/11/17

Y1 - 2022/11/17

N2 - Spencer-Smith et al. (2022)1 investigate multiple functions of the BRAF cysteine-rich domain (CRD), finding distinct classes of RASopathy-associated BRAF mutations and unique features among RAF paralogs that may contribute to the spectrum of mutations observed in disease.

AB - Spencer-Smith et al. (2022)1 investigate multiple functions of the BRAF cysteine-rich domain (CRD), finding distinct classes of RASopathy-associated BRAF mutations and unique features among RAF paralogs that may contribute to the spectrum of mutations observed in disease.

UR - https://www.scopus.com/pages/publications/85141806536

U2 - 10.1016/j.molcel.2022.10.034

DO - 10.1016/j.molcel.2022.10.034

M3 - Comment/debate

C2 - 36400004

AN - SCOPUS:85141806536

SN - 1097-2765

VL - 82

SP - 4192

EP - 4193

JO - Molecular Cell

JF - Molecular Cell

IS - 22

ER -

RASopathy mutations open new insights into the mechanism of BRAF activation

Abstract

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