Abstract
This study was performed to determine the correlation of tumorrasand c-myconcogene expression with clinical and prognostic variables in patients prone to develop colorectal cancer. One hundred eighteen patients with colorectal cancer were studied; mean age was 40 years. Fifty-three were young patients (age 40 or less), 49 had ulcerative colitis, and 16 had multiple polyposis coli. Immunoperoxidase stains of paraffin-embedded cancer sections were performed for the c-mycandrasproteins. rasstaining was found to correlate with Dukes stage and prognosis. Patients with tumors negative forrasprotein stain had an actuarial five-year survival of 61 percent versus 44 percent for those tumors with a positive stain (P<0.05). This correlation was not seen with the c-mycstain. Positiverasoncogene stain appears to be a useful indicator of advanced stage and poor prognosis in colorectal cancer occurring in cancer-prone patients.
Original language | English |
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Pages (from-to) | 430-435 |
Number of pages | 6 |
Journal | Diseases of the Colon and Rectum |
Volume | 35 |
Issue number | 5 |
DOIs | |
State | Published - May 1992 |
Externally published | Yes |
Keywords
- Colorectal cancer
- Multiple polyposis coli
- Oncogenes
- Prognosis
- Young patients
- c-myconcogene
- rasoncogene
- ulcerative colitis