ras and c-myc protein expression in colorectal carcinoma - Study of cancer-prone patients

Felice Miller, Tomas M. Heimann, Astrid Quish, Daniel J. Pyo, Arnold Szporn, Giorgio Martinelli, Thomas M. Fasy

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


This study was performed to determine the correlation of tumorrasand c-myconcogene expression with clinical and prognostic variables in patients prone to develop colorectal cancer. One hundred eighteen patients with colorectal cancer were studied; mean age was 40 years. Fifty-three were young patients (age 40 or less), 49 had ulcerative colitis, and 16 had multiple polyposis coli. Immunoperoxidase stains of paraffin-embedded cancer sections were performed for the c-mycandrasproteins. rasstaining was found to correlate with Dukes stage and prognosis. Patients with tumors negative forrasprotein stain had an actuarial five-year survival of 61 percent versus 44 percent for those tumors with a positive stain (P<0.05). This correlation was not seen with the c-mycstain. Positiverasoncogene stain appears to be a useful indicator of advanced stage and poor prognosis in colorectal cancer occurring in cancer-prone patients.

Original languageEnglish
Pages (from-to)430-435
Number of pages6
JournalDiseases of the Colon and Rectum
Issue number5
StatePublished - May 1992
Externally publishedYes


  • Colorectal cancer
  • Multiple polyposis coli
  • Oncogenes
  • Prognosis
  • Young patients
  • c-myconcogene
  • rasoncogene
  • ulcerative colitis


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