@article{d9d70053430f4c2b9c2b62b08a8d746b,
title = "Rare point mutation at codon 301 and 969 of FMS/M-CSF receptor in acute myelomonocytic and monocytic leukemia",
abstract = "We have investigated whether point mutations occurred at codon 301 or 969 of FMS (M-CSF receptor) in 19 patients with acute myelomonocytic (M4) and monocytic leukemia (M5). Nineteen peripheral blood and bone marrow blood samples collected from M4 and M5 patients were examined by using polymerase chain reaction and hybridization to allele specific oligonucleotide probes. Mutations at codon 301 and 969 of FMS were not detected in any samples. FMS gene mutations at codon 301 and 969 were rarely involved in M4 and M5 patients in Japan.",
keywords = "AML, AMoL, M-CSF, PCR, c-fms, point mutation",
author = "Toshiki Natazuka and Toshimitsu Matsui and Mitsuhiro Ito and Hirohisa Nakata and Toshitaro Nakagawa and Hiroyuki Nakamura and Toru Masaoka and Takashi Isobe and Yoshinobu Nakao",
note = "Funding Information: ACUTE myeloid leukemia (AML) is characterized by abnormal proliferation and differentiation in myeloid lineage cells. Recently, several oncogenes have been demonstrated their involvement in the malignant transformation of hematopoietic cells to leukemic cells. The overexpression of FMS gene products has been reported in acute myelomonocytic leukemia (M4) and monocytic leukemia (M5) \textbackslash{}[1, 2\textbackslash{}]. corms, which is transduced in the feline sarcoma retroviral oncogene (v-fms), encodes for the receptor of the macrophage-colony stimulating factor (M-CSF) \textbackslash{}[3\textbackslash{}]. M-CSF stimulates the growth and differentiation of the monocytic-macrophage lineage cells, and thereby activates these cells functionally. FMS exhibits ligand-dependent protein tyrosine kinase activity. Mutations in the FMS gene can show ligand- * This work was supported by Grants-in-Aid for Scientific Research (0370350) and Cancer Research (03152087,03151069) from the Ministry of Education, Science, and Culture, Japan. Abbreviations: M-CSF, macrophage-colony stimulating factor; M4, acute myelomonocytic leukemia; M5, acute monocytic leukemia; AML, acute myeloid leukemia; MDS, myelodysplastic syndrome; CMMoL, chronic mye-lomonocytic leukemia; PCR, polymerase chain reaction.",
year = "1992",
month = may,
doi = "10.1016/0145-2126(92)90182-7",
language = "English",
volume = "16",
pages = "541--543",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Ltd.",
number = "5",
}