Rare case of anaplastic plasmacytoma in the sinonasal tract

Monica H. Xing, Ariana L. Shaari, John E. Beute, Neil Mundi, Ammar Matloob, Azita S. Khorsandi, Gregory Wisdom, Mark L. Urken

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Extramedullary plasmacytomas are tumors that develop from plasma cells and rarely express anaplastic features. To our knowledge, there have only been three reported cases of anaplastic plasmacytomas of the sinonasal tract in the English literature. We detail the fourth case. Methods: A 70-year-old male was seen with a 4-month history of nasal congestion, bloody mucous, and left sided nasal obstruction. On positron emission tomography/computed tomography, the lesion was FDG-avid with an SUVmax of 25.1. A biopsy of the lesion and subsequent immunohistochemical staining confirmed the diagnosis of an anaplastic plasmacytoma. Results: The patient is undergoing a 5-week course of curative-intent radiation therapy. Conclusion: Extramedullary plasmacytomas with anaplastic features are very rare. We highlight the value of thorough histopathological review and detailed immunostains to arrive at a diagnosis of anaplastic extramedullary plasmacytoma.

Original languageEnglish
Pages (from-to)E46-E50
JournalHead and Neck
Issue number10
StatePublished - Oct 2021


  • anaplastic
  • maxillary sinus
  • nasal cavity
  • plasmacytoma
  • sinonasal tract


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