Rapid cellular turnover in adipose tissue

Alessandra Rigamonti, Kristen Brennand, Frank Lau, Chad A. Cowan

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

It was recently shown that cellular turnover occurs within the human adipocyte population. Through three independent experimental approaches - dilution of an inducible histone 2B-green fluorescent protein (H2BGFP), labeling with the cell cycle marker Ki67 and incorporation of BrdU - we characterized the degree of cellular turnover in murine adipose tissue. We observed rapid turnover of the adipocyte population, finding that 4.8% of preadipocytes are replicating at any time and that between 1-5% of adipocytes are replaced each day. In light of these findings, we suggest that adipose tissue turnover represents a possible new avenue of therapeutic intervention against obesity.

Original languageEnglish
Article numbere17637
JournalPLoS ONE
Volume6
Issue number3
DOIs
StatePublished - 2011
Externally publishedYes

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