RANKL Signaling and ErbB Receptors in Breast Carcinogenesis

Ilianna Zoi, Michalis V. Karamouzis, Christos Adamopoulos, Athanasios G. Papavassiliou

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

ErbB family members, ErbB1/EGFR/HER-1, ErbB2/HER-2, ErbB3/HER-3 and ErbB4/HER-4, have been implicated in breast cancer (BC) tumorigenicity. Recently, crucial roles for RANK/RANKL signaling in addition to key downstream factor NF-κB have been demonstrated in mammary tumorigenesis. Here, we present the hypothesis of a novel association between ErbB and RANK pathways in promoting BC. The proposed model alludes to the cross-talk that might occur between RANK and ErbB receptors. This interplay might regulate RANK signaling and consequently, modulate carcinogenesis, mainly in ErbB2 over-expressing BC cells. Thus, we highlight the significance of the RANK/RANKL axis as a putative therapeutic target in this malignancy, and furthermore, suggest that the combination of ErbB and RANK/RANKL inhibitors may have therapeutic benefit for certain BC patients.

Original languageEnglish
Pages (from-to)839-850
Number of pages12
JournalTrends in Molecular Medicine
Volume22
Issue number10
DOIs
StatePublished - 1 Oct 2016
Externally publishedYes

Keywords

  • ErbB
  • ErbB2
  • NF-κB
  • RANK
  • breast cancer

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