Randomized trial of high-dose cytarabine versus amsacrine in acute myelogenous leukemia in relapse: A leukemia intergroup study

W. R. Vogler, H. D. Preisler, E. F. Winton, A. J. Gottlieb, J. Goldberg, J. Brennan, H. Grunwald, K. Rai, G. Browman, K. B. Miller

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Patients with acute myelogenous leukemia in relapse who were ineligible for further anthracycline therapy either because they were judged to be anthracycline resistant or had received the maximum doses were randomized to receive high-dose cytarabine (3 g/m2 every 12 hours for 6 days) or amsacrine (75 mg/m2 daily for 7 days). The response rates in both groups were similar: three of 25 patients given high-dose cytarabine and three of 23 given amsacrine obtained complete remissions.

Original languageEnglish
Pages (from-to)455-459
Number of pages5
JournalCancer Treatment Reports
Volume70
Issue number4
StatePublished - 1986

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