TY - JOUR
T1 - Randomized controlled trial of patching vs acupuncture for anisometropic amblyopia in children aged 7 to 12 years
AU - Zhao, Jianhao
AU - Lam, Dennis S.C.
AU - Chen, Li Jia
AU - Wang, Yunxiu
AU - Zheng, Chongren
AU - Lin, Qiaoer
AU - Rao, Srinivas K.
AU - Fan, Dorothy S.P.
AU - Zhang, Mingzhi
AU - Leung, Ping Chung
AU - Ritch, Robert
PY - 2010/12
Y1 - 2010/12
N2 - Objective: To compare the effectiveness of 2-hour daily patching with the effectiveness of acupuncture in treating anisometropic amblyopia in children aged 7 to 12 years who have worn optimal spectacles for at least 16 weeks. Methods: In a single-center randomized controlled trial, 88 eligible children with an amblyopic eye who had a best spectacle-corrected visual acuity (BSCVA) of 0.3 to 0.8 logMAR at baseline were randomly assigned to receive 2 hours of patching of the sound eye daily or 5 sessions of acupuncture weekly. All participants in our study received constant optical correction, plus 1 hour of nearvision activities daily, and were followed up at weeks 5, 10, 15, and 25. The main outcome measure was BSCVA in the amblyopic eye at 15 weeks. Results: The mean BSCVA of the amblyopic eye at 15 weeks improved from baseline by 1.83 and 2.27 lines in the patching and acupuncture groups, respectively. After baseline adjustment, the mean difference of BSCVA between the 2 groups was 0.049 logMAR (95% confidence interval, 0.005-0.092; P=.03), meeting the definition of equivalence (difference within 1 line). The BSCVA had improved by 2 lines or more in 28 (66.7%) and 31 (75.6%) eyes in the patching and acupuncture groups, respectively. Amblyopia was resolved in 7 (16.7%) and 17 (41.5%) eyes in the patching and acupuncture groups, respectively. Conclusion: Acupuncture produced equivalent treatment effect for anisometropic amblyopia, compared with patching, and was statistically superior. Further studies are warranted to investigate its value in the treatment of amblyopia. Clinical Relevance: Acupuncture could potentially become an alternative treatment to occlusion therapy for amblyopia. Trial Registration: Centers for Clinical Trials Registry Identifier: CUHK-CCT00248.
AB - Objective: To compare the effectiveness of 2-hour daily patching with the effectiveness of acupuncture in treating anisometropic amblyopia in children aged 7 to 12 years who have worn optimal spectacles for at least 16 weeks. Methods: In a single-center randomized controlled trial, 88 eligible children with an amblyopic eye who had a best spectacle-corrected visual acuity (BSCVA) of 0.3 to 0.8 logMAR at baseline were randomly assigned to receive 2 hours of patching of the sound eye daily or 5 sessions of acupuncture weekly. All participants in our study received constant optical correction, plus 1 hour of nearvision activities daily, and were followed up at weeks 5, 10, 15, and 25. The main outcome measure was BSCVA in the amblyopic eye at 15 weeks. Results: The mean BSCVA of the amblyopic eye at 15 weeks improved from baseline by 1.83 and 2.27 lines in the patching and acupuncture groups, respectively. After baseline adjustment, the mean difference of BSCVA between the 2 groups was 0.049 logMAR (95% confidence interval, 0.005-0.092; P=.03), meeting the definition of equivalence (difference within 1 line). The BSCVA had improved by 2 lines or more in 28 (66.7%) and 31 (75.6%) eyes in the patching and acupuncture groups, respectively. Amblyopia was resolved in 7 (16.7%) and 17 (41.5%) eyes in the patching and acupuncture groups, respectively. Conclusion: Acupuncture produced equivalent treatment effect for anisometropic amblyopia, compared with patching, and was statistically superior. Further studies are warranted to investigate its value in the treatment of amblyopia. Clinical Relevance: Acupuncture could potentially become an alternative treatment to occlusion therapy for amblyopia. Trial Registration: Centers for Clinical Trials Registry Identifier: CUHK-CCT00248.
UR - http://www.scopus.com/inward/record.url?scp=78650143272&partnerID=8YFLogxK
U2 - 10.1001/archophthalmol.2010.306
DO - 10.1001/archophthalmol.2010.306
M3 - Article
C2 - 21149771
AN - SCOPUS:78650143272
SN - 0003-9950
VL - 128
SP - 1510
EP - 1517
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 12
ER -