TY - JOUR
T1 - Randomized Comparison of Allogeneic Versus Autologous Mesenchymal Stem Cells for Nonischemic Dilated Cardiomyopathy
T2 - POSEIDON-DCM Trial
AU - Hare, Joshua M.
AU - DiFede, Darcy L.
AU - Rieger, Angela C.
AU - Florea, Victoria
AU - Landin, Ana M.
AU - El-Khorazaty, Jill
AU - Khan, Aisha
AU - Mushtaq, Muzammil
AU - Lowery, Maureen H.
AU - Byrnes, John J.
AU - Hendel, Robert C.
AU - Cohen, Mauricio G.
AU - Alfonso, Carlos E.
AU - Valasaki, Krystalenia
AU - Pujol, Marietsy V.
AU - Golpanian, Samuel
AU - Ghersin, Eduard
AU - Fishman, Joel E.
AU - Pattany, Pradip
AU - Gomes, Samirah A.
AU - Delgado, Cindy
AU - Miki, Roberto
AU - Abuzeid, Fouad
AU - Vidro-Casiano, Mayra
AU - Premer, Courtney
AU - Medina, Audrey
AU - Porras, Valeria
AU - Hatzistergos, Konstantinos E.
AU - Anderson, Erica
AU - Mendizabal, Adam
AU - Mitrani, Raul
AU - Heldman, Alan W.
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2017/2/7
Y1 - 2017/2/7
N2 - Background Although human mesenchymal stem cells (hMSCs) have been tested in ischemic cardiomyopathy, few studies exist in chronic nonischemic dilated cardiomyopathy (NIDCM). Objectives The authors conducted a randomized comparison of safety and efficacy of autologous (auto) versus allogeneic (allo) bone marrow-derived hMSCs in NIDCM. Methods Thirty-seven patients were randomized to either allo- or auto-hMSCs in a 1:1 ratio. Patients were recruited between December 2011 and July 2015 at the University of Miami Hospital. Patients received hMSCs (100 million) by transendocardial stem cell injection in 10 left ventricular sites. Treated patients were evaluated at baseline, 30 days, and 3-, 6-, and 12-months for safety (serious adverse events [SAE]), and efficacy endpoints: ejection fraction, Minnesota Living with Heart Failure Questionnaire, 6-min walk test, major adverse cardiac events, and immune biomarkers. Results There were no 30-day treatment-emergent SAEs. Twelve-month SAE incidence was 28.2% with allo-hMSCs versus 63.5% with auto-hMSCs (p = 0.1004 for the comparison). One allo-hMSC patient developed an elevated (>80) donor-specific calculated panel reactive antibody level. The ejection fraction increased in allo-hMSC patients by 8.0 percentage points (p = 0.004) compared with 5.4 with auto-hMSCs (p = 0.116; allo vs. auto p = 0.4887). The 6-min walk test increased with allo-hMSCs by 37.0 m (p = 0.04), but not auto-hMSCs at 7.3 m (p = 0.71; auto vs. allo p = 0.0168). MLHFQ score decreased in allo-hMSC (p = 0.0022) and auto-hMSC patients (p = 0.463; auto vs. allo p = 0.172). The major adverse cardiac event rate was lower, too, in the allo group (p = 0.0186 vs. auto). Tumor necrosis factor-α decreased (p = 0.0001 for each), to a greater extent with allo-hMSCs versus auto-hMSCs at 6 months (p = 0.05). Conclusions These findings demonstrated safety and clinically meaningful efficacy of allo-hMSC versus auto-hMSC in NIDCM patients. Pivotal trials of allo-hMSCs are warranted based on these results.
AB - Background Although human mesenchymal stem cells (hMSCs) have been tested in ischemic cardiomyopathy, few studies exist in chronic nonischemic dilated cardiomyopathy (NIDCM). Objectives The authors conducted a randomized comparison of safety and efficacy of autologous (auto) versus allogeneic (allo) bone marrow-derived hMSCs in NIDCM. Methods Thirty-seven patients were randomized to either allo- or auto-hMSCs in a 1:1 ratio. Patients were recruited between December 2011 and July 2015 at the University of Miami Hospital. Patients received hMSCs (100 million) by transendocardial stem cell injection in 10 left ventricular sites. Treated patients were evaluated at baseline, 30 days, and 3-, 6-, and 12-months for safety (serious adverse events [SAE]), and efficacy endpoints: ejection fraction, Minnesota Living with Heart Failure Questionnaire, 6-min walk test, major adverse cardiac events, and immune biomarkers. Results There were no 30-day treatment-emergent SAEs. Twelve-month SAE incidence was 28.2% with allo-hMSCs versus 63.5% with auto-hMSCs (p = 0.1004 for the comparison). One allo-hMSC patient developed an elevated (>80) donor-specific calculated panel reactive antibody level. The ejection fraction increased in allo-hMSC patients by 8.0 percentage points (p = 0.004) compared with 5.4 with auto-hMSCs (p = 0.116; allo vs. auto p = 0.4887). The 6-min walk test increased with allo-hMSCs by 37.0 m (p = 0.04), but not auto-hMSCs at 7.3 m (p = 0.71; auto vs. allo p = 0.0168). MLHFQ score decreased in allo-hMSC (p = 0.0022) and auto-hMSC patients (p = 0.463; auto vs. allo p = 0.172). The major adverse cardiac event rate was lower, too, in the allo group (p = 0.0186 vs. auto). Tumor necrosis factor-α decreased (p = 0.0001 for each), to a greater extent with allo-hMSCs versus auto-hMSCs at 6 months (p = 0.05). Conclusions These findings demonstrated safety and clinically meaningful efficacy of allo-hMSC versus auto-hMSC in NIDCM patients. Pivotal trials of allo-hMSCs are warranted based on these results.
KW - endothelial function
KW - heart failure
KW - idiopathic dilated cardiomyopathy
KW - immune biomarker
KW - stem cell therapy
UR - http://www.scopus.com/inward/record.url?scp=85011650223&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2016.11.009
DO - 10.1016/j.jacc.2016.11.009
M3 - Article
C2 - 27856208
AN - SCOPUS:85011650223
SN - 0735-1097
VL - 69
SP - 526
EP - 537
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 5
ER -