Radiosynthesis of 3-indolyl[1-11C]acetic acid for phyto-PET-imaging: An improved production procedure and formulation method

Youwen Xu, David L. Alexoff, Anna T. Kunert, Wenchao Qu, Dohyun Kim, Max Paven, Benjamin A. Babst, Richard A. Ferrieri, Michael J. Schueller, Joanna S. Fowler

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

An improved production procedure and formulation method for the carbon-11 radiolabeled phytohormone, 3-indolyl-[l-11C]acetic acid ([11C]IAA), was developed by modifying selected original reaction parameters. This updated procedure both doubled the yield (from 25.9±6.7% (n=12) to 61.0±0.3% (n=10)) and increased the concentration (0.2-0.4GBq/0.15-0.3mL), enabling us to provide the radiotracer [11C]IAA suitable for in vivo phyto-PET-imaging studies. The specific activity was improved by more than a factor of three (26.7±5.6GBq/μmol to 82.5±36.1GBq/μmol). The total synthesis time for both production and formulation was 81.8±3.0min (n=10). In addition, a streamlined semi-remote controlled production system, containing five processing modules, was designed and built for routine [11C]IAA production. This integrated system facilitated routine high radiation level production of [11C]IAA while minimizing radiation exposure to the production chemists.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalApplied Radiation and Isotopes
Volume91
DOIs
StatePublished - Sep 2014
Externally publishedYes

Keywords

  • Formulation
  • Phyto-PET-imaging
  • Radiochemical yield
  • Specific activity

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