Radionuclide imaging of experimental atherosclerosis with nonspecific polyclonal immunoglobulin G

A. J. Fischman, R. H. Rubin, B. A. Khaw, P. B. Kramer, R. Wilkinson, M. Ahmad, M. Needelman, E. Locke, N. D. Nossiff, H. W. Strauss

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The utility of nonspecific polyclonal IgG for external imaging of experimental atherosclerosis was tested in a series of rabbits after balloon catheter deendothelialization of the abdominal aorta. Following injection of 111In-IgG, 111In-Fc, or 111In-Fab serial images were recorded. In addition, several animals received 125I-low density lipoproteins [125I-LDL], or 125I human serum albumin [125I-HSA] as positive and negative controls. Forty-eight hours after injection of the radiolabeled proteins, the aortas were removed, divided into abdominal and thoracic regions, counted and autoradiographed. The images acquired after injection of 111In-IgG and 111In-Fc, showed clear focal accumulation of radioactivity in the healing abdominal aorta. In contrast, the images obtained after injection of 111In-Fab did not show focal radionuclide accumulation. For 111In-IgG and 111In-Fc there were three to six times as many counts in the abdominal as in the thoracic aorta, while for 111In-Fab and 125I HSA, the abdominal and thoracic counts were nearly equal. The results suggest that radiolabeled IgG and Fc can be used to image experimental atherosclerosis.

Original languageEnglish
Pages (from-to)1095-1100
Number of pages6
JournalJournal of Nuclear Medicine
Issue number6
StatePublished - 1989
Externally publishedYes


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