TY - JOUR
T1 - Radiolabeled, nonspecific, polyclonal human immunoglobulin in the detection of focal inflammation by scintigraphy
T2 - Comparison with gallium-67 citrate and technetium-99m-labeled albumin
AU - Rubin, R. H.
AU - Fischman, A. J.
AU - Needleman, M.
AU - Wilkinson, R.
AU - Callahan, R. J.
AU - Khaw, B. A.
AU - Hansen, W. P.
AU - Kramer, P. B.
AU - Strauss, H. W.
PY - 1989
Y1 - 1989
N2 - The accumulation of nonspecific polyclonal human immunoglobulin (IgG) radiolabeled with 125I or 111In was compared to that of [67Ga]citrate and [99mTc]albumin in rats with deep thigh inflammation due to Escherichia coli infection. Serial scintigrams were acquired at 1, 3, 24, and in some cases, 48 hr after injection. As early as 3 hr postinjection, [111In]IgG showed greater accumulation at the lesion than [99mTc]HSA (p < 0.01). Both [125I]IgG and [111In]IgG showed greater accumulation than [67Ga]citrate (p < 0.01). At 24 hr, IgG image definition increased, while HSA image definition decreased, and the intensity of accumulation of both IgG preparations was greater than that of [67Ga]citrate or [99mTc]HSA (p < 0.01). At all imaging times, [67Ga]citrate accumulation was surprisingly low. In inflammation produced by Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans, or turpentine, [111In]IgG accumulation was similar to the results obtained with Escherichia coli. These studies suggest that focal sites of inflammation can be detected with radiolabeled nonspecific human polyclonal IgG.
AB - The accumulation of nonspecific polyclonal human immunoglobulin (IgG) radiolabeled with 125I or 111In was compared to that of [67Ga]citrate and [99mTc]albumin in rats with deep thigh inflammation due to Escherichia coli infection. Serial scintigrams were acquired at 1, 3, 24, and in some cases, 48 hr after injection. As early as 3 hr postinjection, [111In]IgG showed greater accumulation at the lesion than [99mTc]HSA (p < 0.01). Both [125I]IgG and [111In]IgG showed greater accumulation than [67Ga]citrate (p < 0.01). At 24 hr, IgG image definition increased, while HSA image definition decreased, and the intensity of accumulation of both IgG preparations was greater than that of [67Ga]citrate or [99mTc]HSA (p < 0.01). At all imaging times, [67Ga]citrate accumulation was surprisingly low. In inflammation produced by Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans, or turpentine, [111In]IgG accumulation was similar to the results obtained with Escherichia coli. These studies suggest that focal sites of inflammation can be detected with radiolabeled nonspecific human polyclonal IgG.
UR - http://www.scopus.com/inward/record.url?scp=0024505696&partnerID=8YFLogxK
M3 - Article
C2 - 2738667
AN - SCOPUS:0024505696
SN - 0161-5505
VL - 30
SP - 385
EP - 389
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 3
ER -