Radioimmune assay of heterologous serum γ-globulin in patients receiving rabbit antihuman thymocyte globulin

Charles P. Bieber; Eva Lydick; Randall B. Griepp; Lyle A. David; Philip E. Oyer; Edward B. Stinson

doi:10.1097/00007890-197511000-00006

Radioimmune assay of heterologous serum γ-globulin in patients receiving rabbit antihuman thymocyte globulin

Charles P. Bieber
, Eva Lydick
, Randall B. Griepp
, Lyle A. David
, Philip E. Oyer
, Edward B. Stinson

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A radioimmune assay (RIA) method for detecting heterologous serum rabbit γ-globulin (RG) and antibody to this protein is described. The methodology is used for monitoring serum levels of rabbit globulin in patients receiving rabbit ATG (RATG). In 7 cardiac recipients receiving RATG, maximum serum levels of RG were achieved 1-3 days after administration of final dose. RG half-life subsequent to peak serum levels was rapid (X = 36 hr) in 4 patients and prolonged (X = 18 days) in 3 patients. Patient antibody to rabbit γ-globulin was detectable only in those patients with short RG half-life. Antirabbit antibody titers in these patients were extremely low and barely detectable by RIA.

Original language	English
Pages (from-to)	393-398
Number of pages	6
Journal	Transplantation
Volume	20
Issue number	5
DOIs	https://doi.org/10.1097/00007890-197511000-00006
State	Published - Nov 1975
Externally published	Yes

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@article{e15b95b760fc42738a189bbabf46af44,

title = "Radioimmune assay of heterologous serum γ-globulin in patients receiving rabbit antihuman thymocyte globulin",

abstract = "A radioimmune assay (RIA) method for detecting heterologous serum rabbit γ-globulin (RG) and antibody to this protein is described. The methodology is used for monitoring serum levels of rabbit globulin in patients receiving rabbit ATG (RATG). In 7 cardiac recipients receiving RATG, maximum serum levels of RG were achieved 1-3 days after administration of final dose. RG half-life subsequent to peak serum levels was rapid (X = 36 hr) in 4 patients and prolonged (X = 18 days) in 3 patients. Patient antibody to rabbit γ-globulin was detectable only in those patients with short RG half-life. Antirabbit antibody titers in these patients were extremely low and barely detectable by RIA.",

author = "Bieber, \{Charles P.\} and Eva Lydick and Griepp, \{Randall B.\} and David, \{Lyle A.\} and Oyer, \{Philip E.\} and Stinson, \{Edward B.\}",

year = "1975",

month = nov,

doi = "10.1097/00007890-197511000-00006",

language = "English",

volume = "20",

pages = "393--398",

journal = "Transplantation",

issn = "0041-1337",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Radioimmune assay of heterologous serum γ-globulin in patients receiving rabbit antihuman thymocyte globulin

AU - Bieber, Charles P.

AU - Lydick, Eva

AU - Griepp, Randall B.

AU - David, Lyle A.

AU - Oyer, Philip E.

AU - Stinson, Edward B.

PY - 1975/11

Y1 - 1975/11

N2 - A radioimmune assay (RIA) method for detecting heterologous serum rabbit γ-globulin (RG) and antibody to this protein is described. The methodology is used for monitoring serum levels of rabbit globulin in patients receiving rabbit ATG (RATG). In 7 cardiac recipients receiving RATG, maximum serum levels of RG were achieved 1-3 days after administration of final dose. RG half-life subsequent to peak serum levels was rapid (X = 36 hr) in 4 patients and prolonged (X = 18 days) in 3 patients. Patient antibody to rabbit γ-globulin was detectable only in those patients with short RG half-life. Antirabbit antibody titers in these patients were extremely low and barely detectable by RIA.

AB - A radioimmune assay (RIA) method for detecting heterologous serum rabbit γ-globulin (RG) and antibody to this protein is described. The methodology is used for monitoring serum levels of rabbit globulin in patients receiving rabbit ATG (RATG). In 7 cardiac recipients receiving RATG, maximum serum levels of RG were achieved 1-3 days after administration of final dose. RG half-life subsequent to peak serum levels was rapid (X = 36 hr) in 4 patients and prolonged (X = 18 days) in 3 patients. Patient antibody to rabbit γ-globulin was detectable only in those patients with short RG half-life. Antirabbit antibody titers in these patients were extremely low and barely detectable by RIA.

UR - https://www.scopus.com/pages/publications/0016762546

U2 - 10.1097/00007890-197511000-00006

DO - 10.1097/00007890-197511000-00006

M3 - Article

C2 - 54964

AN - SCOPUS:0016762546

SN - 0041-1337

VL - 20

SP - 393

EP - 398

JO - Transplantation

JF - Transplantation

IS - 5

ER -

Radioimmune assay of heterologous serum γ-globulin in patients receiving rabbit antihuman thymocyte globulin

Abstract

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